mild cognitive impairment nayana
TRANSCRIPT
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Welcome
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Advancement in medical science
Decline in mental health
Thrust area - Mental health care
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WHO predicts by 2025, about 75% population- people aged
60 years and older People with dementia will almost double every
20 years 42.3 million in 2020 and 81.1 million in 2040. Prevalence of MCI in India is about 14.89%
Increasing risk - COGNITIVE IMPAIRMENT
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Ayurveda is a lifestyle Preventive domain Treatment domain
Ayurveda
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Mild Cognitive Impairment (MCI) An Ayurvedic Preventive Approach
ScholarDr.NAYANA.SMD ScholarMano vijnan avum manas rogaDept of kayachikitsaVPSV Ayurveda CollegeKottakkal
GuideDr.JITHESH.MAssociate ProfessorVPSV Ayurveda College
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Cognitive decline
Affects memory ,thinking and reasoning
Transition stage
What is MCI?
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Presence of cognitive complaint
Absence of dementia
Change from normal functioning
Decline in any area of cognitive functioning
Diagnostic criteria
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Amnestic (memory impairment)
Non amnestic (non memory cognitive domains)
Subtypes of MCI
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Mini mental status examination
Modified MMSE
Diagnostic tools
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Apoptosis or programmed cell death of neurons
Insufficient nootropic factors
Failure to establish neuronal connections
MCI-Pathogenesis
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Increasing age
Decreased mentally stimulating activities
Other medical conditions
Risk factors
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Alzheimer's disease or other type of dementia.
Studies suggest 6 to 15% develop dementia every year
Fate of MCI
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Depression Irritability and aggression Affects QoL Anxiety Apathy
Associated Mental disturbances
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Treatments for Alzheimer’s disease
Antioxidants
Cholinesterase inhibitors
Donepezil
Adverse effects
Present trends in treatment in modern medicine
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NEED FOR AYURVEDIC INTERVENTION
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Concept of Jnanotpathi- Perception Attention Comprehension
Concept of medha, budhi and smruthi
Ayurvedic perspective of cognition
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The highest form of budhi-acts at subtle levels.
Grahana sakthi (grasping power)
Dharana sakthi (retention power)
Medha
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Discriminating power
Smrithi drushta (seen) shrutha (heard) anubhuta (experienced)
Budhi
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Smrithibudhi Hraasa (memory intellect decline)
Smrithibhramsa (memory derangement)
CHRONOLOGICAL DETERIORATION
MEDHA - 4th decade
BUDDHI- 9th decade
MCI -Ayurvedic view
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INTELLECTUAL ERROR
Aaharaja –dietary factors
Viharaja- Lifestyle factors COGNITIVE IMPAIRMENT Manasika-psychic factors
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COGNITIVE NEUROREHABILITATION
NOOTROPIC AGENTS
NEUROPLASTICITY
NEUROREHABILITATION
Intervention -Approach
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Medhya rasayana
Centella asiatica (Mandookaparni)-juice
Glycirriza glabra (yashti madhu)-powder with milk
Tinospora cordifolia (guduchi)-paste
Clitoria ternatea (sankhupushpi)-paste
Nootropic agents
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Centella asiatica
Effect of Centella asiatica on cognition and oxidative stress in an intra cerebro ventricular streptozotocin model of Alzheimer’s disease in rats ( Veerendra kumar et al)
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Glycyrrhiza glabra
Concept of Nootropic drugs(Pharmacognosy review, Reena kulkarni et al)
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Tinospora cordifolia
Preventive trial on progression of mild cognitive impairment through cognitive enhancement by guduchi satva (DR.JADHAV AVINASH BHAGVAT RAO)
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Clitorea ternatea
Concept of Nootropic drugs(Pharmacognosy review, Reena kulkarni et al)
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Bacopa monnieri
Effect of Bacopa monnieri on animal models of Alzheimer’s disease and pertubed central cholinergic markers of cognition in rats (Bhattacharya et al)
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Withania somnifera
Pharmacology Biochemistry and Behaviour, SK Bhattacarya et al, Adaptogenic activity of Withania somnifera – an experimental study using rat model of chronic stress, vol 75, pp547-555
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Nardostachys jadamansi
Concept of Nootropic drugs(Pharmacognosy review, Reena kulkarni et al)
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Acorus calamus
Concept of Nootropic drugs(Pharmacognosy review, Reena kulkarni et al)
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Withania somnifera(aswagandha)
Nardostachys jadamansi(jadamanchi)
Acorus calamus(vacha)
Bacopa monneiri(brahmi)
Nootropic agents…
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Preventive trial on progression of mild cognitive impairment through cognitive enhancement by guduchi satva
(DR.JADHAV AVINASH BHAGVAT RAO)
Clinical efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment (DR.M S BAGHEAL et al)
Relevant studies
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Polyherbal preparation of ghee
Naladadi ghritha
Kalyanaka ghritha Ghee- Site specificity
Nootropic drugs…ghritha
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• Ability of the brain to shape itself according to experience
• Physical change on a neuronal level
Neuroplasticity
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Budhimedhakara gana- susrutha acharya
“Satataadhyayana vaada paratantra avalokanamTadvidya aacharya seva cha budhimedhakaro gana”
Continuous learning Engaging in debates Studying other sciences Learning from experts
Tips to stimulate neuroplasticity
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In a broader sense we can include the techniques
Brain games Learning new languages Playing musical instruments Cross words
Neuroplasticity …
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Panchakarma therapy
Snehapana, Virechana, Sirovasthi, Sirodhara, Nasya
Yoga
Meditation
Neurorehabilitation
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Nasya
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Sirovasthi
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Sirodhara
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Vitalizer of psyche and soma Socio-behavioural conducts for moral or
mental hygiene
Effective preventive principles for psychological disorders
Achara rasayana
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Achara Rasayana in three dimensions:
Personality
Social Relationship
Physical Health
Mode of action
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Need of promotion of mental health
Early management of MCI
Conclusion
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Nootropic drugs-medhya rasayana
Brain exercises
Panchakarma procedures
Ayurveda as a treatment…
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Adoption of good behavioral conducts -achara rasayana
Timely intervention of lifestyle diseases
Periodic intake of medhya rasayana
Active involvement in intellectually stimulating activities
Preventive…..
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