technology transfer
DESCRIPTION
TRANSCRIPT
SEMINAR ONSEMINAR ON
TRANSFER OF
TECHNOLOGY
TRANSFER OF
TECHNOLOGY
PRESENTED BY-CHANDAN Kr. SINGHM.Pharm ( 2nd SEM)
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April 10, 2023
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¤ INTRODUCTION
¤ WAYS “TECHNOLOGY” IS TRANSFERRED
¤ TECHNOLOGY TRANSFER AGENT
¤ TYPES OF TECHNOLOGY
¤ CONSTITUENTS OF TECHNOLOGY TRNSFER
¤ CONENTS OF TECHNOLOGY TRANSFER
¤TECHNOLOGY TRANSFER TEAM & RESPONSIBILITY
¤ FUNCTIONS OF TECHNOLOGY
¤ FACTOR AFFECTING TECHNOLOGY
¤TECHNOLOGY TRANSFER CHECKLIST
¤ EXAMPLES OF TECHNOLOGY TRANSFER
¤ REFERENCES
CONTENTS
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INTRODUCTION
It is a process which is mainly concerned with the transfer of technology from the research areas to the “Production and Quality Assurance” environment .
The Process by which existing knowledge , facilities or capabilities developed under R & D funding are utilized to fulfill public and private need.
“Technology Transfer” includes a range of formal & informal cooperation between technology developers and technology seekers.
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Varied Roles
IDEA
Research
Development
Production
Manufacturing
Distribution
Start-upFirms
R & DFirms
LargerCompanies
Universities
ResearchInstitutes
MARKET
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Ways “Technology” is Transferred
Consulting
Graduating students (“moving heads”)
Faculty moving on (“moving heads”)
Collaborative research
Patenting and licensing
Service and outreach (“extension”)
Spin-off companies
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Technology Transfer Agents
R&D Units• Universities• Public Research Centers• Technology Institutes(institutions, labs etc)
R&D Units• Universities• Public Research Centers• Technology Institutes(institutions, labs etc)
Companies• Supplier of technologyand R&D to third parties• Spin-off, start-ups• Large R&D department• Competitors, suppliers…(technological alliances)
Companies• Supplier of technologyand R&D to third parties• Spin-off, start-ups• Large R&D department• Competitors, suppliers…(technological alliances)
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TYPES OF TECHNOLOGY
1) EMERGING TECHNOLOGY- is an innovative technology that currently is undergoing bench scale testing, in which a small version of the technology is tested in a laboratory.
2) INNOVATIVE TECHNOLOGY- is a technology that has been field tested and applied to a hazardous waste problem at a site, but lack a long history of full-scale use.
3) ESTABLISHED TECHNOLOGY- is a technology for which cost and performance information is readily only after a technology has been used at many different sites and the result fully documented is that technology considered. established.
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CONSTITUENTS OF TECHNOLOGY TRANSFER PROCESS
Technology Transfer
Technology Promotion
Technology Deployment
Technology innovation
Technology Development
Technology Research
Technology Assessment
Technology Information and
Communication
Technology Investment
Technology Collaboration
Technology
Commercialization
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CONTENT OF TECHNOLOGY TRANSFER
6 P
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Proper Research – By proper research we mean firstly that in which the result are reproducible and issues such as scale up, stability etc and other practical now has been addressed, also that in which problem were taken up in first place.
Proper Research – By proper research we mean firstly that in which the result are reproducible and issues such as scale up, stability etc and other practical now has been addressed, also that in which problem were taken up in first place.
Proper work- This refer to institutional and guidelines regarding IP Protection licensing modalities etc. which must be in place beforehand. In the absence of these, decision get delayed, lack of fairness in decision e.g. case of X institute, which came up with good technology but since no guidance were there, kept running around for two years and then gave up.
Proper work- This refer to institutional and guidelines regarding IP Protection licensing modalities etc. which must be in place beforehand. In the absence of these, decision get delayed, lack of fairness in decision e.g. case of X institute, which came up with good technology but since no guidance were there, kept running around for two years and then gave up.
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Pricing – most difficult and critical area of Transfer of technology. - Too high price can put off buyer, leaving the technology unsold. - Too price a result in revenue loss. - There are basically two model regarding pricing1)Price charged for a technology should depend upon market force i.e. impact of the technology irrespective of amount spent on developing it.2)Price charged should include all expenses involved in developing it.
Publicity – It is important to identify and then approach buyer i.e. adopt targeted Publicity and not blanket publicity. Specific journal, website, letters to manufacturer, personal selective visit etc. are some common approach which help in locating buyer.
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Partnership – this means working along with industry. Industry takes it up, manufacturer and makes available to society. Partnership are important to ensure your technology is successfully adopted simply conveying the details may not be sufficient.
Partnership – this means working along with industry. Industry takes it up, manufacturer and makes available to society. Partnership are important to ensure your technology is successfully adopted simply conveying the details may not be sufficient.
People’s Acceptance – It is no use trying to develop a technology which people will not accept e.g. due to religious reason/social concern etc. genetically modified food, irradiated vegetables processed beef in India, improved capsule made of non-vegetarian material.
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LIST OF INSTITUTE IN INDIA ASSISSTING IN TECHNOLOGY TRANSFER
Asia pacific centre for Transfer of technology ( APCTT)
Technology Bureau for small enterprises ( TBSE)
National Research & Development corporation
Foundation for Innovation and Technology Transfer
Process technologist
• central focus for transfer activities• collates documentation from donor site• perform initial assessment of transferred project for a) feasibility b) compatibility with site capabilities c) establishes resource requirements
Representative Review documentation to determine compliance with Marketing authorization (MA) Review analytical methods with QC to determine capability, equipment training requirements.Initiate conversion of donor site documentation into local system/formatInitiate or confirm regulatory requirement, e.g. change to manufacturing license , variations to MA if process changes needed, etc.
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Proposed Team Member and Their Responsibilities
Production representative
Review process instructions (with process technologist) to confirm capacity/ capability Considers any safety implication e.g. solvents, toxic, sanitizing materialsConsider impact on local standard operating procedures (SOPs)Consider training requirement of supervisors/ operator
Engineering representative
Review (with production representative) equipment requirement Initiate required engineering modification/ change/ part purchase.Review preventative maintenance/ calibration impact, e.g. use of more aggressive ingredients: more temperature sensitive process, and modifies accordingly.
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FUNCTION OF TECHNOLOGY TRANSFER TEAM
1) Coordinate- Coordinating between technology users and developer, between researcher and manufacturers is important element of technology transfer.
2) Nurture- A main ingredient for moving technology from a research laboratory to a new business enterprises successfully in an environment that is supportive for entrepreneurship.
3) LINK- Cataloging resources related to business enterprises & connecting would be entrepreneurship / researcher and other
technology developers to outside group & organization which can help in the process of starting new product, companies etc.
such linkage provide referrals for individual business counseling, sources of financing.
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FACTOR AFFECTING TECHNOLOGY TRANSFER
TIPS Method ( Technology implementation Potential for Success)
TIPS Method ( Technology implementation Potential for Success)
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TECNOLOGY TRANSFERCHECKLIST
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EXAMPLES OF TECHNOLOGY TRANSFER
CHINA
L – Phenyl alanineBy enzyme method
(Ref : APC – 4041 – TOF)
# Chinese company offer technology for the production of L- Phenyl alanine by the enzyme method.
Area of Application # Food industryAdvantage- Low input Advanced process No environmental contamination Clear production
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Stage of development commercialized
Economic data Total project cost 4 million Equipment 1.38million
Transfer form Known how, consultancy, equipment, training
Target country world wide
Language English
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A Novel, Non-infringing Process for the manufacture of levobupivacaineA Novel, Non-infringing Process for
the manufacture of levobupivacaine
NIPER, mohali offer a non-infringing process for the manufacturer of an improved widely used local anesthetic, levobupivacaine.
The process uses a chiral catalyst for asymmetric synthesis of the product.
Area of Application Local anesthetic product widely used in hospital in surgical procedure.
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Advantage of technology Uses easily available raw material Faster compared to existing process as no resolution involved. Cheaper as use of expensive resolving agent is altogether eliminated Non-infringing new process
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Stage of Development Process at laboratory scale Scale up to be done Facilities for scale up exist at institute ( pilot plant available)
Economic Data Product name – Chirocane, ( approved clinically) No manufacturer in India till date Transfer form Technology licensing and Known how
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Manufacturer of Pharmaceutical Raw Materials,
Pharmacopoeial Fine Chemicals,
Active Nutraceuticals,
Laboratory Reagents (Bulk)
(LR /AR/ ACS/FCC)
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Nutraceuticals
Pharmacopoeial Fine Chemicals
EDTA Fine Chemicals
Phosphates Fine Chemicals
Azithromycin APIs Sorbic Acid & Potassium Sorbate Potassium Phthalimide
Citrate Fine Chemicals
Inositol & Inositol Nicotinate
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TECHNOLOGIES TRANSFER : Bimal pharma PVT. Ltd. A team of technically highly qualified technocrats in the pharmaceutical field, having experience of manufacturing of API, intermediates, pharma fine chemicals and pharma formulations, for more than 25 years, they offer complete “turn-key” project services including detailed engineering, complete demonstration of manufacturing processes of all apis; intermediates for apis; pharma fine chemicals and pharma formulations. They are also experts in supplying the best quality intermediates / penultimate stages, along with technologies to make final apis to suit your US FDA / WHO-GMP approved manufacturing units for different countries.
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REFERENCES
1) Ira R. Berry, “ Technology Transfer Consideration for Pharmaceuticals”, Encyclopedia of Pharmaceutical Technology, Third Edition, 02 oct. 2006, pp. no. 20-30.
2) http://www.gdrc.org/uem/techtran.html
3) Luis Alberto del Río, Salazar N., and Trives C.“Guidelines for a pharmaceutical technology transfer towards a drug manufacturing plant”, Comunicaciones técnicas, Bol. Soc. Quím. Méx. 2007, 1(1), pp no. 27-31
4) http://bud.tic.ab.ca/venquest/yqt_home.htm
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