the uses of nanosensors: from smart dust to nano “mother ships”
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Environmental sampling,Smart Dust Kris Pister, UCB (1996),Silicon nanostructures mimic the beetle shellTRANSCRIPT
The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”
Jack Ealy WorkshopLa Jolla, CA July 2006
Professor Michael J. SailorUC San Diego
Dept. of Chemistry and [email protected]
http://chem-faculty.ucsd.edu/sailor/
Death on the Danube
The Economist, 2/15/00The Economist, 2/15/00
Environmental sampling
Field
Lab
Smart DustKris Pister, UCB (1996)
Available:•wireless radios•data processing•networkingprotocols
Smart DustKris Pister, UCB (1996)
Need:•sensors•power sources
Silicon vapor sensors
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Making a silicon nanostructure
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Electrochemical machiningof nanopores
Silicon nanostructures mimic the beetle shell
a
chitinmultilayern = 1.73n = 1.40
Calloodes grayanus
2 mm
Chitin multilayer
Silicon nanostructures mimic the beetle shell
Silicon multilayer
Silicon Microsensors
William R. Freeman, M.D. and Lingyun Cheng, M.D.
Jacobs Retina CenterUCSD
Mother-Ships for Nanotherapies
color changes when particle releases drug
Porous silicon micro-particle in
the eye
Ruoslahti, Cancer Cell, 2002
UCSD Moores Cancer CenterNIH nanoTUMOR center
Erkki Ruoslahti, Burnham Inst.Sangeeta Bhatia, MITMichael Sailor, UCSD
Diagnostic
Therapeutic
Activation
Targeting Self-Destruct
Sensor
Targeted Nanomachines
Backup slides
As with any new technology, reasonable concerns about potential hazards are appropriate.
Hazards of nanotechnology
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University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997-
January 1998)
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Asbestos fibers (Nikon, inc)
Hazards of nanotechnology
Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003).
Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004).
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5 nm CdSe (A. Paul Alivisatos, UC
Berkeley)
Making a silicon nanostructure
20 mQuickTime™ and aH.263 decompressorare needed to see this picture.
Encoded particles self-assemble
a
oxidizedalkylated
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Magnetic manipulation of microparticles
Nature Mater. 2004, 3, 896-899.
a
30 nm magnetitenanoparticles[O]