第 4 章 细胞因子药物
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4 ,cytokine
-
interferon IFN
,
-
IFN-25
IFN- 4
IFN- TNK4 I pH 2601hII
-
IFN-188189N23165166
human interferon-alpha 2b maltfallva llvlsckssc svgcdlpqth slgsrrtlml laqmrrislf sclkdrhdfg fpqeefgnqf qkaetipvlh emiqqifnlf stkdssaawd etlldkfyte lyqqlndlea cviqgvgvte tplmkedsil avrkyfqrit lylkekkysp cawevvraei mrsfslstnl qeslrske
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IFN- IFN-IFN- 802530 IFN-203Cys1
-
IFN-INF-IFN-
N2314316 kD
-
IFN-IFN-
IFN-
-
IFN
-
IFN
IFN-T
-
IFN1.5-2.8 h
SchgringPEGIFN,PEG Intron1.5g/kg l
-
IFN
(r-med IFN-consenseus Interferon)Intergen
11IFN-IFN
NK
-
IFNIFN(ribavirin)RebetolIFN
IFN-IFNTNF
-
IFN
l2
-
232530
IFN-
-
Interleukin ILIL
-
23IL-lIL-23
IL-2IL-11IL-6IL-10IL-12
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IL-2 TNK, IL-2
133 aa15-17.5kDa6.8-8.23Cys, Cys58Cys1051 myrmqllsci alslalvtns aptssstkkt qlqlehllld lqmilnginn yknpkltrml 61 tfkfympkka telkhlqcle eelkpleevl nlaqsknfhl rprdlisnin vivlelkgse 121 ttfmceyade tativeflnr witfcqsiis tlt interleukin-2 [Homo sapiens].
-
Cys125,,
Cys125,
N-aa,N-1-20aa
-
41pH29
-
IL-2IL-2
IL-2
-
IL-2T
T(CTL)
NKNK
-
LAK(TIL)
B
IL-2
-
(IFN)(TNF)(CSF)NK
()IL-2
-
IL-2IL-2
(LAK)
IL-2
-
IL-2 T
-
IL-2
-
IL-11IL-11199aaN-21aaCys11.7,80 ,
-
Met59C-aaIL-11.
Lys42Lys993.
-
IL-11 IL-11
IL-11
-
IL-11 G-CSF
IL-11
IL-11N58
IL-Il
-
ILIL-2()
IL-2
IL-2(PEG)
IL-2
IL-2(DAB3891L-2,ONTAK)1L-2T
-
Colony stimulating factorCSF G-CSF GM-CSF M-CSF multi-CSF EPO TPO SCF
-
1. G-CSF()
-
4,4-8
Cys17,,
-
2. M-CSF
522 aa32 aa
M-CSFM-CSF
-
M-CSF
-
3. GM-CSFT
GM-CSF144 aaN-17 aa
18-32 kDa, 2
2N-O-
GM-CSF
-
GM-CSF46
56 10 min
pH 2
-
GM-CSFGM-CSF
-
4 Erythropoietin EPO193 aa27 aa
EPO165
rhEPOEPO,CHO
-
EPOEPO
-
AmgenEpogen
-
5 Stem cell factor SCF(stem cell growth factorSCGF
(mast cell growth factorMGF)
1990
-
SCF
-
SCFSCF
SCF273 aaN2518936
SCF
-
AmgenSCF
-
6 Epidermal growth factor, EGFEGF2060533 6 kDa
-
(hEGF)
EGFBrunner, EGF
-
EGFEGF203l EGF
NC
-20
-
6Cys
-
EGFEGF
EGF
EGF
EGF
-
EGF ()
EGF EGFEGFEGF
-
EGF
EGF
EGF
rhEGF
-
7 Fibroblast growth factor FGF
23
bFGFhFGF1996
bFGF
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