急性大腸菌性乳房炎と診断された乳牛に対する 乳房...

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─ 99 ─ 急性大腸菌性乳房炎と診断された乳牛に対する 乳房内洗浄療法の治療効果 篠塚 康典 1)2)* 平田 晴美 2) 石橋 一郎 2) 大川 雄三 2) 春日 朝子 2) 高木 光博 3) 田浦 保穂 1) Therapeutic Efficacy of Mammary Irrigation Regimen in Dairy Cattle Diagnosed with Acute Coliform Mastitis YASUNORI SHINOZUKA 1, 2) *, HARUMI HIRATA 2) , ICHIRO ISHIBASHI 2) , YUZO OKAWA 2) , ASAKO KASUGA 2) , MITSUHIRO TAKAGI 3) , and YASUHO TAURA 1) 1Laboratory of Veterinary Surgery, United Graduate School of Veterinary Medicine, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, 2Yamagata Veterinary Clinical Center, 461-1 Haruki, Kitahiroshima, Hiroshima 731-1531 3Laboratory of Farm Animal Production Medicine, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan SUMMARY ABSTRACT. The objective of this field study was to determine the therapeutic efficacy of mammary irrigation for the treatment of dairy cattle diagnosed with acute coliform mastitis caused by gram-negative bacteria. Additionally, the effects of different mammary irrigation regimen fluids such as ozone water and normal saline were compared. Dairy cattle clinically diagnosed with acute coliform mastitis (n=57) were enrolled in the study, randomly assigned to 1 of 3 groups, and received the following treatments: systemic antibiotic administration (SAA group; n=40), mammary irrigation regimen (MIR group; n=10), and both treatments (MIX group; n=7). Significant antipyretic effects, as assessed by rectal temperature measurement, were observed in the MIX and MIR groups. Although 2 irrigating fluids were used, namely, ozone water and normal saline, no significant difference was observed between the 2 groups. Fourteen days after the onset of the treatments, the milk yield recovery rate in MIR group tended to be higher (p=0.06) than that in the SAA group. Additionally, after 30 days of treatment, the MIR group cows demonstrated significantly higher successful recovery rates (p<0.05) than the SAA group cows. These results indicate that mammary irrigation with normal saline is an effective treatment for acute coliform mastitis in dairy cattle. 1)山口大学大学院連合獣医学研究科家畜外科学講座(山口市吉田 1677-1) 2)NOSAI 広島山県家畜診療所(山県郡北広島町春木 461-1) 3)鹿児島大学農学部獣医学科臨床獣医学講座産業動物獣医学分野(鹿児島市郡元 1-21-24) *連絡先 篠塚康典 E-mail: [email protected] 投稿先:日本獣医学会誌 J. Vet. Med. Sci. 71 (3) : 269-273, 2009

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Page 1: 急性大腸菌性乳房炎と診断された乳牛に対する 乳房 …hiro-vet.or.jp/_src/98190/p99-100_20161213161210082.pdfirrigation regimen fluids such as ozone water and normal

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急性大腸菌性乳房炎と診断された乳牛に対する乳房内洗浄療法の治療効果

篠塚 康典1)2)* 平田 晴美2) 石橋 一郎2) 大川 雄三2)

春日 朝子2) 高木 光博3) 田浦 保穂1)

Therapeutic Effi cacy of Mammary Irrigation Regimen in Dairy Cattle Diagnosed

with Acute Coliform Mastitis

YASUNORI SHINOZUKA1, 2)*, HARUMI HIRATA2), ICHIRO ISHIBASHI2), YUZO OKAWA2),

ASAKO KASUGA2), MITSUHIRO TAKAGI3), and YASUHO TAURA1)

1) Laboratory of Veterinary Surgery, United Graduate School of Veterinary

Medicine, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515,

2) Yamagata Veterinary Clinical Center, 461-1 Haruki, Kitahiroshima,

Hiroshima 731-1531

3) Laboratory of Farm Animal Production Medicine, Faculty of Agriculture,

Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan

SUMMARY

ABSTRACT. The objective of this fi eld study was to determine the therapeutic effi cacy

of mammary irrigation for the treatment of dairy cattle diagnosed with acute coliform

mastitis caused by gram-negative bacteria. Additionally, the effects of different mammary

irrigation regimen fluids such as ozone water and normal saline were compared. Dairy

cattle clinically diagnosed with acute coliform mastitis (n=57) were enrolled in the study,

randomly assigned to 1 of 3 groups, and received the following treatments: systemic

antibiotic administration (SAA group; n=40), mammary irrigation regimen (MIR group;

n=10), and both treatments (MIX group; n=7). Signifi cant antipyretic effects, as assessed

by rectal temperature measurement, were observed in the MIX and MIR groups. Although

2 irrigating fluids were used, namely, ozone water and normal saline, no significant

difference was observed between the 2 groups. Fourteen days after the onset of the

treatments, the milk yield recovery rate in MIR group tended to be higher (p=0.06) than

that in the SAA group. Additionally, after 30 days of treatment, the MIR group cows

demonstrated signifi cantly higher successful recovery rates (p<0.05) than the SAA group

cows. These results indicate that mammary irrigation with normal saline is an effective

treatment for acute coliform mastitis in dairy cattle.

1)山口大学大学院連合獣医学研究科家畜外科学講座(山口市吉田 1677-1)2)NOSAI 広島山県家畜診療所(山県郡北広島町春木 461-1)3)鹿児島大学農学部獣医学科臨床獣医学講座産業動物獣医学分野(鹿児島市郡元 1-21-24)  *連絡先 篠塚康典 E-mail: [email protected]投稿先:日本獣医学会誌 J. Vet. Med. Sci. 71(3) : 269-273, 2009

Page 2: 急性大腸菌性乳房炎と診断された乳牛に対する 乳房 …hiro-vet.or.jp/_src/98190/p99-100_20161213161210082.pdfirrigation regimen fluids such as ozone water and normal

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広島県獣医学会雑誌 № 24(2009)

要   約

 本臨床研究の目的は,グラム陰性桿菌による乳牛の急性大腸菌性乳房炎の治療として乳房内洗浄療法の治療効果をあきらかにすることである.さらに,乳房内洗浄に用いる洗浄液としてオゾン水と生理的食塩水の効果を比較した.急性大腸菌性乳房炎と診断された乳牛(57頭)を次の 3つの治療群に分け,ランダムに割り当てた.全身抗生物質投与群(SAAグループ 40

頭),乳房内洗浄療法群(MIRグループ 10頭),そしてこれらの併用群(MIXグループ 7頭)である. MIXグループとMIRグループにおいて,治療翌日の有意な直腸温の低下を認めた.オゾン水と生理的食塩水を用いて乳房内洗浄療法を行ったがいずれも差は認められなかった.治療 14日後において,SAAグループに対してMIRグループは乳量を回復させる傾向があった(p=0.06).さらに,30日後の治癒率はMIRグループは SAAグループに対して有意に高かった(p<0.05).これらのことから,生理的食塩水による乳房内洗浄療法は急性大腸菌性乳房炎に対して有効であるといえる.