Introduction To Biomedicine生物醫學概論

Chung W.Wu, M.S.,R.Ph.

Extension:-----5213

1. The Story of Biomedicine Applications of Biomedicine

(1)  Monosodium Glutamate Reaction

(2)  Caffeine

(3) Chromophore:IndigoChemical Structure of Curcumin

 

  

 Chemical Structure of Desmethoxy Curcumin   

 

 Chemical Structure of Bis-desmethoxy Curcumin  

  

(4) How to Create New Molecule

(5) Nucleic Acid

(6) Quinine

2. DNA(Gene) Recombinant3. Trace Element4. Biotechnology5. Immunological Reaction6. Life & Biochemistry

1. PTFE Polytetrafluoroethylene Chemical Inert Artificial Blood VesselInner Diameter: 4—10mm人工韌帶

2.Collagen:Natural Polymer From animal 1000 Amino Acids

---Polypetide Content33.5% Glycine12% Proline10% Hydroxyproline

Triple HelixTropocollagen Collagen Fiber

CollagenExtract from animal tissue事先 treatment of cross-linking 避免免疫排斥

才能植入人體良好生物相容性

(1). 細胞培養基材

(2). 人工器官基材

(3). 組織填充材料

3. 矽膠矽膠充填物：豐胸下巴隆鼻矽膠隆乳婦女 1980------1990發現分解碎片可能改變婦女Immune System ，引起風濕性關節炎。導致 Dow Corning 倒閉。

But:

血漿可能含有可以殺死乳癌細胞的物質，患乳癌機率降低。

4.Glucosamine

Poly(beta-1,4-N-acetyl-D-Glucosamine)Polymer of NAG昆蟲與甲殼類動物之外骨骼 蝦蟹外殼

無毒性 生物相容性 生物體內可分解 價格便宜

Usage:生醫材料 人工細胞外間質 傷口敷料

化妝品

7.Taxol PaclitaxelA plant product of high current interes

t in cancer chemotherapy.Isolation from the bark ofPacific yew tree Taxus brevifolia byWani et al.in 1971.

Found to have antitumor activity

Taxol inhibits mitosis by acting as a spindle poison

8.Deadly ToxinBlock Neurotransmitter ReleaseBotulinum ToxinsFlaccid ParalysisBlcking the release of AchAt the neuromuscular junction

Injection into Facial MuscleTo Remove Wrinkles

10.Bromelain(Ananase) Extract from Pineapple

廢棄鳳梨莖含有大量蛋白質分解酵素

Dole Company 最早生產Proteolytic EnzymeUsage: 治療外傷組織發炎燒燙傷 發炎後形成之腫脹可能是組織間隙充滿 Fibrin 而 Bromelain 可破壞Fibrin 分子。

11.Urokinase Glycosylated Serine Protease Usage: 尿液中強力血塊溶解作用 腦血栓及血栓靜脈炎

12.Lactase(beta-Galactosidase)

Milk------------Lactose Reduced MilkOriental,Black,& Part White Adults Small amount of LactaseThey can’t drink MilkMilk: Lactose Intolerance Watery Diarrhea Flatulence

Production of LactaseSaccharomyces fragilisKluyveromyces lactisCandida pseudotropicalisAspergilus nigerAspergilus oryzae

1975 Italy Snam Progetti Yeast----LactaseCellulose acetate fiberDauly Production of Lactose-Reduced Milk: 8000 liter

13. Glucose Isomerase

100% Glucose Syrup---42% Fructose

1.5 times Sweeter than Glucose Same Calories

1970 USA Clinton CornProcessing CompanyHigh Fructose Syrup(HFS)pH 7.5~8.0, 60C,500,000 Tons/year

14.Penicillin Amidase(Acylase) pH 7.8 Hydrolyse Benzylpenicillin to form 6-APA

1972 USA Squib CompanyEscherichia coliPenicillin Amidase