nextstep nano-tera 2015

1

Drill integrated neuro-monitoring for minimally invasive robotic cochlear implantation> Background

Drill passes within 0.3 1 mm of facial nerve

> Facial nerve safety preliminary work Neuromonitoring for FN protection (detect FN proximity) Optimal stimulation protocol determined in sheep Custom neuromonitoring probe detects FN ( Project Goal Drill integrated stimulation for conitinuous FN monitoring

> Proposal Protocol verification in humans (medical grade EMG device

required) (Neurosign device, 17000 CHF ) Drill bit insulation coating for integrated stimulation

electrodes (Student 2.5 months ~ 14,000 CHF) Total budget 31,000 CHF, project duration 6 months

> Collaborators Marco Caversaccio, Department of ENT, Unibe Jorg Patscheider, Coatings department, Empa

Anode 1Anode 2Anode 3

Cathode

-1 0 10.10.30.5

1

1.5

Stim

ulus

thre

shol

d (m

A)

Axial distance (mm)

Sheep 2Trajectory 7LD = 0

d = 2d = 4d = 7Mono

FN

Juan Ans, May 2015

NextStep - Scientific Collaboration04.05.2015 - Tobia Brusa, ISTB, University Bern

> Functional anatomy of Fecal Incontinence (FI) Characterization of continence organs anatomy and biomechanics in

patients suffering from fecal incontinence (FI). Prof. Dr. Med. Radu Tutuian, chief physician gastroenterology at

Tiefeneau Hospital Bern Chf: ~30000.-

> Extension of current Nano-Tera study aiming at defining design specifications of implant based on healthy volunteers.

> Main benefit: add clinical component to the project Comprehensive assessment of contraction and compliance Integration of imaging and functional data Establishing normal (healthy subjects vs. patients) Develop new treatment concepts

1

DigitalUltrasoundHead[UltrasoundToGo]PascalAlexanderHager

Cable64256coax

ImageSources:Ibmt.fraunhofer.de

healthcare.philips.comwww.akutron.com/products

Digitalhighspeedlink

ProjectScope

Transducerhead BackendSystemAnalogFrontend DigitalProcessing

Conventional2DUltrasoundSystem:

PiezoelectricTransducerArray

FrontendHDIPCB(commercialcomponents)

BackendSystemFPGABoard

(Tablet/Smartphone)

UltrasoundDivisionFraunhofer IBMT

ETHZIIS

DigitalProcessing

Goal: Explorenewdigitalultrasoundhead concept.Collaboration: Buildtwoheads,collaboratorsprovideparts Funding(30k):PCB,Components,IBMTAssistanceTimeTable: 6Month,50%PhDStudentIIS 10%supportpersonnelIIS/IBMT

largestultrasoundresearchunitEuropemorethan20yearsexperience

Main collaborator: Tommaso Nardi, Laboratory of Composite and Polymer Technology, EPFL Planning work: Work with different polymers and methods for embedding GaAs NWs on equipment of Polymer Lab in EPFLOur part: provide test samples with nanowires, analysis of experiments with SEM, OM and other techniques.Collaborator part: provide new polymer materials, expertise of methods of embedding NWs in polymer, provide equipment for experimentsFunding: 5.000 chf

Flexible PDMS film helps to transfer GaAs nanowire forest from Si substrate to surface of c-Si solar cell

1st Idea: Reliability of NW-polymer composite

Problem with PDMS hardness film with thickness 5 m is very fragileSolution: perform search and analysis of different range of polymers with professional polymer chemist

New polymer material UV curable polyester. High transparence Low viscosity Good adhesion Good hardness

Functional c-Si/GaAs nanowire tandem solar cell

DmitryMikulik,EPFL

2nd Idea: Reliability of GaAs NW solar cells by analyzing spectral and electrical characteristics

Main collaborator: Mikhail Mintairov, Photovoltaics Lab, Ioffe institute, RussiaPlanning work: Measurements and analysis of results of pilot devices in Photovoltaics lab in Ioffe instituteOur part: provide pilot devices based on GaAs NWs, organize joint workshop/visit to discuss resultsCollaborator part: provide different measurements of solar cells, analysis of measurementsFunding: 10.000 chf

Problem: Reliability of GaAs NW based solar cellsSolution: To realize perspective and weak points of GaAs NW based solar cell - spectral, electric and optical measurements must be performed.

Optical measurements: EQY Initial

measurements Reflectance give

information about surface quality

IQY - depends on structure and p-n junction optical properties

Electro-luminescence pattern determination at different temperatures:Could be applied to evaluate the uniformity of nanowires photo-electrical properties

T= 25C, J=100 mA/cm2 T= -190C, J=5 mA/cm2 T= -190C, J=5.5 mA/cm2

Electrical measurements: IV curves in a wide range of irradiance

allows to obtain a number of important characteristics:

Voc-Jsc dependence to form p-n junction IV curve

resistive losses IV as a difference between p-n junction and practical IV curve

GaAs p-i-n nanowires embedded in flexible PDMS film would play a role of second solar cell, placed on top of conventional c-Si solar cell

ITO

ITO

cSisolarcell

Sunlight

PDMS

Functional c-Si/GaAs nanowire tandem solar cell

DmitryMikulik,EPFL

LBB Conductive

polymers Implantables

MNSMicro&Nanofabrication

Wearables

APPROACH

AportableEEGsystem (12k) Biocompatibility studies (8k) Clinicalevaluation (10k)

FUNDING

Embeddingconductivenanostructures insoftsubstrates

PARTNERS

Soft&drybiopotentialelectrodes

GOAL

Contact:MoritzThielen,[email protected]

FlurinStauffer MoritzThielen

MOTIVATION

Wearable health monitoring Braincomputerinterfaces Poorperformance of

commercial systemsEnobio from Neuroelectrics

FacialnerveneuromonitoringisusedtoimprovethesafetyofdrillingintheboneforDCA.

Boneelectricpropertiesrequiredtopredictthedistancebetweendrillbitandnerves.

Budget~30000CHF Costofpersonnel&material Seedprojecttowardssnf proposal

Developmentofanimpedancesetuptostudyelectricandelectrochemicalbonetissueproperties.

Electrochemicaleffects Contacteffects Voltage/frequencydependent Affectedbythetypeofelectrolyte

Bettercharacterizationoftheseeffects CollaborationwithDepartmentofChemistryand

BiochemistryatUniversityofBern&UniversityofBudapest(P.Broeckmann,H.Siegenthaler)

Setupforreliablemeasurementoftheelectrochemicalproperties(optimizestraycapacitance,contactinterface,signal/noiseratio,waveform)

ThomasWyssBalmerISTBUniversityof Berne

2

Therapeu*c Drug Monitoring (TDM)

Today:

[1] Edurant (Rilpivirine) prescribing informa*on

???

3

Today:

[1] Edurant (Rilpivirine) prescribing informa*on

0 6 1 2 1 8 2 4 3 0 3 6

1 0

1 0 0

1 0 0 0

T im e a f te r d o s e [H o u rs ]

Rilp

ivir

ine

Co

nc

en

tra

tio

ns

(ng

/m

L)

Target Cmin=44ng/mL

Cmin < 44ng/mL for 40% of popula;on !

TDM of Rilpivirine (an*retroviral drug)

35 000 000 HIV+ 6300 new infec;on/day

4

Today: Tomorrow:

Therapeu*c Drug Monitoring (TDM)

automated personalized

5

Population-based percentiles

Individual concentration vs time profile dosing schedule suggestion

Predic*on engine (Bayesian approach) Ergonomic soHware

6

DBMS, remote data collection

Easy to integrate (Health Level 7 interface)

EzeCHiel light

Clinical interpretation (TDM) Drug developement

Clinical trials

Aggregation of data for the research

Precision Predic;on modeling Time Interoperability Privacy & Security U;lity User-friendly

7

Team

Dr. Sverine Pe;tprez, Drug models development

Alev;na Dubovitskaya, Data mining, Interoperability

Dr. Manel Aouri, Clinical evalua8on

Prof. T. Buclin, MD Dr. N. Widmer Prof. C. Csajka

A. Chaouch

Dr. M. Guidi

Advisory Board:

Dr. P. Andr

Prof. Y.Thoma

Y. Su]er R. Hooper

Prof. M. Schumacher

Division of Clinical Pharmacology, CHUV Development of drug models, clinical evalua8on

REDS HEIG-VD, HES-SO VS So;ware development, Interoperability

8

Ac*on Plan

9

Ac*on Plan

1/09 Nano-Tera Meeting, Bern| 04 May, 2015

We sell Onsite H2 production system

which is cost effective, cleaner & greener, for fertilizer

and chemical industries

Ready to Launch

Solar Fuel, the smarter way.

SoHHytec


Refineries 20%

Ammonia 53%

Other 20%

Methanol 7%

Our Customer

H2 Usage

Fertilizer and Chemical industries


Problem worth solving:

On site cost effective H2 production using smart combination of concentrated solar energy during day and cheap grid electricity during night using our Integrated PEC device

Lack of cost effective onsite H2 production. 95% of current world H2 production comes from off-site steam reforming of conventional fossil fuels which is

Our Solution:

Not clean & non-renewable

Costly due to specialized transportation

Downscaling the size becomes extremely expensive

Faster degradation of the system

Cleaner & Greener

Highly scalable in size (up/down)

Onsite hence no costly expenses for transportation

Longer and durable life span

Our Opportunity

Lack of cost effective onsite H2

production


Night Operation

Compressor

Storage

Concentrator

H2 O2

H2O

Cheap Grid Electricity

During night

CUSTOMER

PV+ELECTROLYZER

Our Product

Integrate

d PEC

Day Operation


Case Operation Type Price

1 Our System 1.69 $/Kg Great combination of sunlight during day and cheap electricity during night

2 Just electrolysis using electricity (Day + Night)

2.21 $/Kg

Even just day electricity price during the lifespan makes it expensive option

3 Steam reforming requiring transportation

2 $/Kg Transportation alone increase price of hydrogen by 1$/kg* of H2 *Hydrogen Sta.on Compression, Storage, and Dispensing Technical Status and Costs ,G. Parks, R. Boyd, J. Cornish, and R. Remick , NREL Independent Peer Review Report

1 2 3

1.69 $

2.21 $ 2 $

Business Potential

Our H2 Production cost (without CSD) including 15% ROI

1.69 $/Kg

For 50m by 50m system producing 234 Kg H2/ day Exemplary case


How we make Profit

Strategy: 15% ROI plus yearly charges equal to 50% of customers saving potential for next 15 years

day 1 year 1-10 year 10-15

54k $

132k $ 136k $

For the installation of the size of 50m by 50m with 360k $ investment

0

2

1 3 5 7 9 11 13 15 Years

Customers Saving potential Our profits

$/Kg

of H

2

Our system

Distributed steam reforming


Meet our Team

Saurabh Tembhurne CEO and co-founder Doctoral Ass istant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne

Meng Lin CTO and co-founder Doctoral Ass i s tant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne

Prof. Sophia Haussener Scientific Advisor Assistant Professor Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne


Gives as Great Opportunity to showcase and demonstrate our product as well as would be a brilliant chance to make new connections and attract tentative investors


THANK YOU

Wearable sensing devices will represent $47.4B market* in 2019

Wearable electronics should be conformal, light weight and unno6ceable

However current electronic solu@ons are rigid, planar and bulky.

* Source :Onworld Wearable Technologies Consumer Survey

We are a wannabe EPFL Spin-off - Prof. S. P. Lacour: Laboratory for soM bioelectronics interfaces

Target Market: Electronic companies

We provide B2B technological solu6ons to help industrial partners implement systems that can conform to the human body

Robustness, Cost effec6veness Design flexibility

Patent applica@on ongoing, backed by EPFL TTO

SolSticE

SolSticE SolSticE Solar Sticker for Energy

Highest Efficiency MaterialsFlexible

Adhesive

SolSticE SolSticE Applications

SolSticE SolSticE Benchmark

Flexibility

Com

fort

SolSticE SolSticE Planar VS Nanowire

p-doped

n-dopedintrinsic

10 m

SolSticE SolSticE Achievements

Status

First prototype on Si. Peeling procedure

developed. The Silicon wafer can be

reused. The technique is scalable

independently on the wafer size.

SolSticE SolSticE Open Challenges

Status

Realization of high conductivity and flexible contacts.

Iterative optimization of the design.

Scale up.

Princess Astronaut Wizard

SolSticE SolSticE The Team

Jelena Vukajlovic-Plestina

Dmitry Mikulik

Federico Matteini

CTO CEOCOO

November 24, 2015, MIT Media Lab, Cambridge, MA

SolSticE SolSticE
nextstepAnsoBrusaHagerMikulik(2x)ThielenWyss1234

nextstep nano-tera 2015

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