PP047

Squamo us cell carcinoma of the tongue. An 11-year experience George Koloutsos a, Angeliki Cheva b, Konstant inos Paraskevop oulos a,Anna Patrikid ou c, Athanasios Kyrgidis a, Nikolaos Kechagias a,Antonios Tsekos d, Leonidas Sakkas b, Thomas Zarampouk as e,Konstantino s Vahtsevano s a, Kostantinos Antoniad es a

a Department of Oral and Maxillofaci al Surgery, General Hospital G.Papaniko laou, Thessalo niki, Greece b Departme nt of Patholo gy, General Hospital G. Papanikolaou ,Thessaloni ki, Greece c Departme nt of Medicin e, Institut Gustave Roussy, Villejuif, France d Departme nt of Oral and Maxilofacia l Surgery, 424 General Military Hospital, Thessaloniki , Greece e Department of Pathology , Aristoteleion University, Thessalo niki, Greece

Background: Squamous cell carcinoma (SCC) of the tongue is one of the most common cancers in the oral and maxillofac ial region.The incidence of SCC of the tongue has increas ed during the recent decades in the develop ed world. The incidence of occult cervical lymph node metastasis is high in SCC of the tongue and the role ofneck dissect ion in the managem ent and its relevance to locoregio nal control is well known.

Patients: Complete clinical, histopathol ogical and follow up data of88 patients with patholog ically confirmed SCC of the tongue were ret- rospectivel y analysed . All patients were treated at our Oral and Max- illofacial Surgery Department between 2000 and 2010 and all of them underwent a resection of the primary tumor and a neck dissection.

Methods: Overall and disease-f ree survival in relation to demo- graphic characte ristics of the patients and patholog ical features ofthe specime ns is being investig ated. Survival analysis is performed using the Kaplan–Meier analysis, compari sons among groups are analysed using a log-rank test and multivaria te analysis is conduc ted using the cox proport ional hazard model.

Results: They will be presented during the meeting .

doi:10.1016/j.oraloncolo gy.2013.03.290

PP048

Incidence of distant metastas es in H&N Cancer patients: Is chest CT necessar y for all patients? Tarun Mittal, Phillip Ameerally, Arti Hindocha

Departme nt of Oral and Maxillofac ial Surgery, Northamp ton General Hospital, Northamp ton, UK

Introduction: The vast majority of cancers affecting the head and neck are squamous cell carcinoma s. Patients often present late, with advanced stages of disease and thus possess an increased risk of pre- senting with distant metastases, the knowledg e or presence of which dramatica lly alter the treatment and reduce prognosi s. The most common site for metastatic spread is the lung.

SIGN advise that all patien ts with a H&N SCC should under goscreening CT of chest and thorax to identif y distant metastases,regardless of primary tumour stage site or size.

The incidence of synchrono us tumou rs of distant metastas es ishigher in individual s with advanced primary tumours (T3/T4). How- ever there is limited evidence regarding patients with less advanced tumours .

Aims - objectives: Assess the incidence of chest metastases at ini- tial staging in patients with H&N SCC at NGH between January 2010 and June 2013 (40 month s) and to investigate the relationship between tumour size, site, histological features, regiona l lymph node metastases and distant chest metastases.

Method: 250 patients presentin g with newly diagnosed H&N SCC who underwent staging and chest CT were identified and their imag- ing, radiologica l and histopathol ogy reports reviewed retrospectivel y.

Inclusion: Newly diagnosed primary, biopsy proven, H&N SCC Patients underwent Chest CT.

Relevant informati on available Discussed on H&N MDT.Exclusion: Recurren t H&N SCC If Chest CT had not been com-

pleted No all informa tion availabl e.Results: To date, 104 individual s have been analysed , with 6

(5.76%) presenting with suspicious nodes or positive nodes on chest CT. the majority of these being staged as T3/T4. One patien t with aT1N1 (level 2a) tumour presented with nodes that were reported as ‘suspicious ’. A further 150 patients will be analysed during the course of this study.

doi:10.1016/j.oraloncology.2013.03.291

PP049

Growth pattern of micropapi llary thyroid cancer without extra- thyroida l extension predicts central lymph node metastas isYoon Se Lee a, Yun-Sung Lim b, Chang-Gi Woo b, Jin-Choon Lee b,Soo-Geu n Wang b, Kang Dae Lee b, Byung-Joo Lee b

a Departme nt of Otorhinolaryn gology–Head and Neck Surgery, Research Institute for Convergence of Biomedica l Science and Technolog y, Pusan Nationa l University, Yangsan Hospital, Yangsan, Republic of Korea b Department of Otorhino laryngology–Head and Neck Surgery, Pusan Nationa l University Hospital and Medical Research Institute, Pusan,Republic of Korea

Purpose: Although prognostic significance of central lymph node (CLN) metastasis in micropa pillary thyroid cancer (microPTC) is con- troversia l, thoroug h removal of metastat ic lymph nodes may reduce the recurren ce rate. Histologic al or clinical predicting factors for CLN metastas is have been studied to determ ine the adequa te surgic alextent or postope rative adjuvant therapy to eradica te metastat iclymph nodes. However, histologi cal features inside primary tumor were not considered as a predictin g factor for metastasis. In this study, we evaluated the relation ship between specific findings ofmicroPTC and central lymph node metastas is.

Materials and methods: We reviewed the patients who underwent total thyroidectom y and central lymph node (CLN) dissection for microPTC , from January to December, 2011. Growth pattern, fibrosis,and architect ure of tumors were used as histological factors. Fibrosis was classified into three groups; I < 10%, II = from 10% to 50%, and III P 50%. Growth pattern was classified into three groups;A = well-defined, B = well-de fined but solid, C = spiculate or infiltra-tive. The relation ship between CLN metastasis and those histologi cal or clinical factors were analyzed.

Results: Of the 353 patients, 162 had CLN metastasis (45.9%). Chi- square test showed that age, gender, and tumor size were not related to CLN metastasis. Group I (n = 55) had lower rate of CLN metastasis (30.9%) than group II (35.5%) and group III (64.3%, p = 0.043). Group A(n = 28) had lower rate of CLN metastas is (14.3%) than group B(18.2%) and group C (39.8%, p = 0.019). Multivari ate analysis showed that growth pattern was only risk factor for CLN metastasis (oddsratio = 1.972, p = 0.022).

Conclusions : Follicul ar or infiltrative growth pattern of intrapa ren- chymal microPTC is an independ ent risk factor for CLN metastasis This report suggests that tumor behavior in the primary tumor plays a important role in CLN metastas is.

doi:10.1016/j.oraloncology.2013.03.292

S110 Abstracts / Oral Oncology 49 (2013) S93–S156