蛋白質棕櫚酸酯化作用位置之研究與辨識 investigation and identification of protein ...
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蛋白質棕櫚酸酯化作用位置之研究與辨識 Investigation and Identification of Protein Palmitoylation Sites. 指導教授：李宗夷 學生姓名：簡婉 竹、陳昱宏、胡堞. 大綱. 背景介紹 動機 與 目的 研究方法 研究成果. 背景介紹. 棕櫚酸酯化作用 ( palmitoylation ) 是什麼 ? 棕櫚酸酯化作用 是 蛋白質轉譯後，蛋白質上的半胱胺酸 ( cysteine ) 與棕櫚酸 ( palmitic acid) 間形成硫酯鍵 ( thioester bond) 的現象。 重要性 : - PowerPoint PPT PresentationTRANSCRIPT
Investigation and Identification of Protein Palmitoylation Sites
Investigation and Identification of Protein Palmitoylation Sites
(palmitoylation)? (cysteine) (palmitic acid) (thioester bond)
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307:UniprotKB/SwissProt version 99/11/30
Cwindow size11PositiveNegative
libsvmsensitivity (Sn)specific (Sp)accuracy (Acc)Mathew correlation coefficient (MCC)
Sn=
Sp=
Acc=
Mcc=
: AAB62PWMAAPCPSSM: SVMQuickRBFRandomForest: Acc (Best accuracy)SnSp (Balanced sensitivity and specificity)B62+AAPCQuickRBF
- SnSpSn-SpAccMCCB62+AAPCQuickRBF94.43%94.36%0.07%94.38%86.50%B62+AAPCSVM86.02%98.78%-12.75%95.27%87.98%B62+AAPCRandomForest42.49%96.97%-54.48%87.83%49.94%:PPAB-palm(Prediction of Palmitoylation site with AAPC and B62)Model: FASTA:
- :http://140.138.150.145/~s971548/site/index.php
CKSAAPCKSAAPX.B. Wang, L.Y. Wu, Y.C. Wang, N.Y. Deng, Prediction of palmitoylation sites using the composition of k-spaced amino acid pairs, (2009) Protein Eng. Des. Sel., 22, 707-712.http://www.aporc.org/doc/wiki/CKSAAP-Palm
- CKSAAPSnSpAccMCCCKSAAP71.38%99.49%93.6%80.02%PPAB94.43%94.36%94.38%85.50%Thank you for listening! Q&A