第二章 药物代谢动力学 ( pharmacokinetics )
DESCRIPTION
第二章 药物代谢动力学 ( Pharmacokinetics ). 研究内容: 药物体内过程 机体对药物的处置 ( disposition ) 吸收 (absorption) 分布 (distribution) 代谢 (metabolism) 排泄 (excretion) 体内药物浓度(血药浓度)动力学规律. 第一节 药物的跨膜转运. - PowerPoint PPT PresentationTRANSCRIPT
-
Pharmacokinetics disposition (absorption) (distribution) (metabolism) (excretion)
-
1 2 3 4
-
pKapH
-
active transport1 2 3 4
-
(absorption) (per os) (sublingual) (per rectum)
-
(first pass elimination)
() (intravenous injection,iv) (intravenous infusion,iv in drop) (intramuscular injection,im) (subcutaneous injection,sc)
-
5 m 10 m
-
(distribution) D + P DP 99% 1% 98% 2% +
-
131
-
pH pH7.4 pH7.0
-
biotransformation; drug metabolism : ,
-
P450cytochrome P450 enzymatic system : + + +
-
(excretion)
1. 2.pH 3. (
1. 2.pH
-
. Cmax) (Tpeak) (latent period) (persistent period)
-
-
-
F=AUC 100%AUC
F=AUC100 %AUC
-
.. FAUCTpeakCmax
MTCMEC
-
. CL LKg-1 h-1
Vd c A A (mg) Vd = C0 (mg L-1)
-
(half-life time t1/2)
. . . .
-
..
-
t1/2=0.693/k
5t1/2
-
. t1/2=C0/2k0