【 般若黑洞 】 出品

【般若黑洞】出品Northwestern Polytechnic University

基于大分子的

药物控释肿瘤靶向

Polymeric

Tumor-Targeting

Drug Controlled Release

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Drug Load装载 定位

Targeting Drug Release释放

胶束Micelles

树枝状聚合物Dendrimers

Liposomes

微脂囊聚合物 -药物偶联物

Polymer-drugconjugates

Drug Load装载

定位

主动active

被动passive

Targeting

配合基 -受体Ligand-receptor

EPR效应EPR Effect

叶酸cRGD

正常组织癌变部位

Drug Release释放

pH

温度

降解

磁场

UV

电场

内因外因

PDEAEMA

PNIPAM

-s-s-

hydrazone bonds

多层分子设计Molecular Design

嵌段

分子量

端基

ATRP

RAFT

点击化学

超分子 星形

开环

Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

Xiang Lan Wu, Jong Ho Kim

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles asDrug Nanocarriers for Targeted Cancer Therapy

Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla

PEG-SS-PPS: Reduction-Sensitive Disulfide Block CopolymerVesicles for Intracellular Drug Delivery

Xiang Lan Wu, Jong Ho Kim

Folate-Conjugated Thermoresponsive Block Copolymers:Highly Efficient Conjugation and Solution Self-Assembly

Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin

Development of multiple-layer polymeric particles for targeted andcontrolled drug delivery

Bhanuprasanth Koppolu, MS, Maham Rahim,

O

Si

OSi

O Si

SiO

Si

OSi

Si

OSi

OSi

OSi

O Si H

SiO

Si

O

Si

H

OSi

O Si H

SiO

Si

HN

H2N

HN

H2N

HN

H2N

HN

NH2

grafted PNIPAM Shell

β-CD based HBP Core

Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM

Thank you!Polymeric Tumor-Targeting Drug Controlled Release

Northwestern Polytechnic University

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