Bridging the Gap From In Vitro to In Vivo

BioMAP® Diversity Plus Profiling

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BioMAP® Diversity Plus Panel

12 Systems include a variety of immune and tissue cell types

• Primary human vascular cells (endothelial and smooth muscle), epithelial cells (skin

and lung), fibroblasts, myofibroblasts, T cell, B cell, monocytes, macrophages

• Good blend of co-culture and single cell type BioMAP® Systems

• Format: > 140 biomarker readouts; 4-dose, single well format

• Useful for:

• Mechanism of action studies

• Covers most mechanisms represented in BioMAP Database

• Safety-related compound properties

• Efficacy-related activities for autoimmune or inflammatory disease areas

• Business terms

• Single compound profiling with Terms and Conditions, per compound pricing

• Competitive terms for ongoing profiling agreements or large studies

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BioMAP® Diversity Plus Panel (1-6)

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BioMAP® Diversity Plus Panel (7-12)

BioMAP® Diversity Plus – Cell Types & Co-cultures

B cells

Endothelial Cells

Bronchial Epithelial Cells

Keratinocytes

Smooth Muscle Cells

Dermal Fibroblasts

Lung Fibroblasts

Peripheral Blood Mononuclear Cells

Macrophages

BioMAP Systems

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10 primary human cell types

12 assay systems

• Different cell types, co-culture combinations

• Different activation conditions – disease models

BioMAP® Diversity Plus – Biology Covered

Vascular Biology

Wound Healing

Th1 Inflammation

Skin Biology

Th2 Responses

Immune Biology

Th17 Biology

Lung Biology

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BioMAP® Profiling – Process

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Compounds

are ShippedCell Culture Data Analysis

Report

Delivery

BioMAPDatabase

Readout Assays

6-8 weeks (12 systems) 1-2 weeks

Automated, Validated

ProceduresSpecially trained staff

Proprietary Database

and Analysis Software

High Throughput Lab

Program Manager

Bridging the Gap From In Vitro to In Vivo

BioMAP® Diversity Plus ProfilingContact

Carmen Bryant

Program Manager

BioSeek, LLC

cbryant@bioseekinc.com

650-416-7647

BioSeek, LLC310 Utah, #100South San Francisco, CA 94080