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Kuby IMMUNOLOGY

Sixth Edition

Chapter 1

Overview of the Immune System

Copyright © 2007 by W. H. Freeman and Company

Kindt • Goldsby • Osborne

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Metchinikoff,

Phagocytosis, macrophages surrounding a foreign particel

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1990,Ehrlich

Side chain theory

Cells in blood expressed

a variety receptor 

Like key and lock

1950, Clonal selection

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Rota virus, 1million death/yr 

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Pseudomonas ingested by macrophage

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Candida albicans

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Larva of Filaria attacked by macropahges,

120 million infection

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Tyrosine

Serine

Threonine

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105 MBA per cell

Secreted Ab

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EM of APC (right) associating with T lym

CTLs (cytotoxic T lymphocytes)

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Lag phase 5-7d

B cell, Th, Plasma cellLag phase 1-2d

Memory B cells

100-1000 folds

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 Allergic reaction to a bee sting

Immune Dysfunction: Allergies and asthma—anaphylaxis (anaphlactic reaction),

dog against toxin from jellyfish, physalia. IgE and Mast ce

Graft rejection and graft vs host disease, bone marrow transplantation, antigraft

1930,Landsteiner ABO grouping, 1980 Thomas and Murry, MHC

 Autoimmune disease—multiple sclerosis, Crohn’s disease, Rheumatic,Immunodeficiency, IgA lacking, SCID (T, B cells ), AIDS

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 Asthma

Food allergy

Tree nut, peanuts

3 million American

Ban peanuts from school and airplaEpinephrine injection or suction