MUSCULAR SYSTEM

JIRANYA BUREEMASB.N.S (2nd class honors) M.Sc (Pharmacology) Tarn_ji@yahoo.com Faculty of Nursing, Vongchavalitkul University

:

Sliding filament mechanism FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

muscle)

(Skeletal (Cardiac (Smooth

muscle)

muscle)

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

Characteristic of Muscle

Contractility: FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

Excitability/ Irritability:

Tendon Skeletal muscle Epimysium Perimysium Endomysium Fascicle Muscle fiber Myofilament

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

Muscle cell/ Muscle fiberCell membrane Cytoplasm Endoplasmic reticulum

Sarcolemma Sarcoplasm Sarcoplasmic reticulum

MUSCLE FIBER/ MUSCLE CELLTransverse tubule (T-tubule)

Muscle Triad T-tubule excitation-contraction coupling

Terminal cisterna SR , The Phraya Phakdi Chumpol Collage of Nursing

Triad

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

myofibril nucleus & mitochondria

Fibril

fibril Filament

Myofilament 2 Thick filament

myosin Thin filament

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

actin, tropomyosin troponin

Thin filament

Thick filament

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

THICK FILAMENT

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

THIN FILAMENT

thick filament A band

I band thin filament I band Z line Z line S

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

thin filament A band A band A bandzone H M line

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

myosin (cross-bridge) thin filament sarcomere sarcomere FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

(sliding) thin filament thi Relaxed myosin actinContracted

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

action potential

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

(Exitation of skeletal muscle) N (NMJ)

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

TriadAction potential T-tubule

SR Ca2+ cytoplasm

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

filament

*** thin filament

myosin actin

Sequential events of contraction

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

muscle relaxation

** Ca++ SR

Rigor mortis

( actin myosin

ATPFACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

FACULTY OF NURSING, VONGCHAVALITKUL UNIVERSITY

1 2 3 4 5 6 7 8 9

Sample question

A skeletal muscle cell A. has light and dark bands (striations) B. has only one nucleus C. is under involuntary control D. None of the above are true

1.2.

thin filament thick filament SR SR Muscle triad Thin filament myosin Troponin 3 myosin actin

3.4. 6.

5.

Sample question

The stages in muscle contraction include a A. nerve impulse reaching a neuromuscular junctionB. nerve impulse stimulating the release of calcium ions C. actin filaments sliding past myosin filaments

D. all the above are true

Sample question

During muscular contractionA. actin and myosin filaments slide past each other. B. ATP supplies energy.

C. calcium ions (Ca++) are involved.D. all of the above

Sample question

At a neuromuscular junction,A. a nerve impulse causes the release of a neurotransmitter

B. a neurotransmitter causes calcium to be released into the

muscle cellC. A & B D. none of the above

tendon - connects skeletal muscle to bone epimysium - fibrous connective tissue around belly of skeletal muscle fasiculi - bundles of muscle fibers perimysium - connective tissue surrounding fasiculi endomysium - connective tissue surrounding the individual muscle fibers (muscle muscle fiber - single muscle cell (threadlike in shape) sarcolemma - membrane surrounding the muscle fiber sarcoplasm - specialized cytoplasm of muscle fiber containing multiple nuclei and myofibrils - "rod-like" structures running through the muscle fibers that contain th

Motor Unit: single motor neuron and all of the fibers it innervates twitch - response to single stimulus (