药物效应动力学 pharmacodynamics
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药物效应动力学 Pharmacodynamics. Pharmacodynamics What the drug does to the body - Drug receptors - Effects of drug - Responses to drugs - Toxicity and adverse effects of drugs. Pharmacodynamics. Dose Response Curve. 激动药结合区域. N. 膜外. 膜内. G 蛋白偶联. C. G-protein coupled recptors. 激动药结合区域. - PowerPoint PPT PresentationTRANSCRIPT
药物效应动力学药物效应动力学PharmacodynamicsPharmacodynamics
PharmacodynamicsWhat the drug does to the body
- Drug receptors- Effects of drug- Responses to drugs- Toxicity and adverse effects of drugs
PharmacodynamicsDose response curve…...
Morphine
Aspirin
From Nierenberg W and Melmon KL. Introduction to Clinical Pharmacology in Clinical Pharmacology: Basic Principles in Therapeutics, Third edition, 1992, Melmon KL et al., editors, p 1-51, McGraw Hill.
Dose Response Curve
G 蛋白偶联
C
N
激动药结合区域
膜外
膜内
G-protein coupled recptors
激动药结合区域
膜外
膜内
激动药结合区域
Ligand-gated ion channel receptors
激动药结合区域
膜外
膜内
催化结构区域
Tyrosine-protein kinase receptor
激动药结合区域
膜外
膜内
DNA 结合区域
转录激活区域
载体 + 药物 载体 - 药物复合物
载体 + 药物载体
Intracellular receptors