中華民國比較病理學會 - 國立臺灣大學 · 2012-08-26 · 1...

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1 C C h h i i n n e e s s e e S S o o c c i i e e t t y y o o f f C C o o m m p p a a r r a a t t i i v v e e P P a a t t h h o o l l o o g g y y 第 49 次比較病理學研討會 國立臺灣大學獸醫專業學院 臺北市.臺灣 中華民國 99 年 7 月 10 日 49th Meeting of Comparative Pathology School of Veterinary Medicine, National Taiwan University Taipei, Taiwan July 10, 2010

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中中華華民民國國比比較較病病理理學學會會 CChhiinneessee SSoocciieettyy ooff CCoommppaarraattiivvee PPaatthhoollooggyy

第第 4499 次次比比較較病病理理學學研研討討會會 國國立立臺臺灣灣大大學學獸獸醫醫專專業業學學院院

臺臺北北市市臺臺灣灣

中中華華民民國國 9999年年 77 月月 1100 日日

4499tthh MMeeeettiinngg ooff CCoommppaarraattiivvee PPaatthhoollooggyy SScchhooooll ooff VVeetteerriinnaarryy MMeeddiicciinnee NNaattiioonnaall TTaaiiwwaann UUnniivveerrssiittyy

TTaaiippeeii TTaaiiwwaann

JJuullyy 1100 22001100

2

中華民國比較病理學會第 49 次比較病理學研討會議程表

Schedule

49th Meeting of the Chinese Society of Comparative Pathology

時間99年 7 月 10 日(星期六) 0900~1600

地點國立臺灣大學獸醫學系 B01 演講廳

地址臺北市羅斯福路四段 1號

電話 02-33663858

Date July 10 2010 (Sat) 0900~1600

Location B01 School of Vet Med NTU

Address No 1 Sec 4 Roosevelt Road Taipei

Telephone 02-33663858

Time 時間 Schedule 議程 Moderator 主持

0830~0900 Registration 報到

0900~0910 Opening Ceremony 致詞

Dr CH Liu

劉振軒 理事長0910~1010 Keynote 專題演講

Blockade of AT1R modulates autoimmunity in the

chronic graft-versus-host disease model of lupus

nephritis

Dr SM Ka 賈淑敏 博士 National Defence Medical Center

國防醫學院醫學系病理學科

1010~1030 Coffee Break

1030~1100 Case 340病例討論

Dr YL Chen 陳燕麟 醫師 Department of Pathology Cardinal Tien Hospital

天主教耕莘醫院病理科

Dr FJ Leu

呂福江 主任 1100~1130

Case 341病例討論

Dr CW Shih 施洽雯 醫師 Department of Pathology Lotung Poh-Ai Hospital

羅東博愛醫院病理科

1130~1200 Case 342病例討論

Dr PR Wu 吳佩儒 醫師 Dept of Surgical Path Changhua Christian Hospital

彰化基督教醫院病理科 1200~1330 Lunch amp Board Meeting 午餐暨「中華民國比較病理學會理監事會議」

1330~1400 Case 343病例討論

YR Chen 陳盈妊 醫學生 Tzu Chi University amp Tzu Chi General Hosipital

佛教慈濟綜合醫院暨慈濟大學

Dr YH Hsu

許永祥 主任

1400~1430 Case 344病例討論

Dr JP Jhu 祝志平 醫師 Department of Pathology Lin Shin Hospital

林新醫院病理科

1430~1500 Case 345病例討論

Dr TT Huang 黃婷姿獸醫師 College of Vet Med National Chung-Hsing University

國立中興大學獸醫學院

1500~1530 Case 346病例討論

Dr TY Chan 詹德裕 獸醫師 School of Veterinary Medicine National Taiwan University

國立臺灣大學獸醫專業學院

1530~1600 General Discussion 綜合討論

3

Table of Contents (目錄)

A Schedule (議程表)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 2

B Table of Contents (目錄)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 3

C Case Signalment⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 4

D Case Diagnosis⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 5

E Keynote Speaker⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 6

F Comparative Pathology Case 340⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 7

Comparative Pathology Case 341⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 11

Comparative Pathology Case 342⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 16

Comparative Pathology Case 343⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 20

Comparative Pathology Case 344⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 23

Comparative Pathology Case 345⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 27

Comparative Pathology Case 346⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 32

G 中華民國比較病理學會數位式組織切片影像資料庫⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 35

H 1~49 次研討會病例分類表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 40

I 中華民國比較病理學會章程⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 59

J 會員資料更新服務⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 63

K 入會辦法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 64

L Map (國立臺灣大學獸醫專業學院)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 66

4

中華民國比較病理學會第 49 次比較病理學研討會

Case Signalment

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Signalment

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH 59- year-old man

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023 53-year-old woman

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A 59-year-old woman

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 47-year-old man

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 40-year-old woman

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Pheasant-tailed jacana

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32A3-to-4-year-old

mixed-breed dog

5

中華民國比較病理學會第 49 次比較病理學研討會

Case Diagnosis

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Diagnosis

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH

Mucinous-producing

urothelial-type

adenocarcinoma of

prostate

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023

Pulmonary placental

transmogrification

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A

Plexiform

fibromyxoma

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 Malignant epithelioid

trophoblastic tumor

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 Epithelioid sarcoma

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Acute carbofuran

intoxication

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32ATransmissible

venereal tumor

6

Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

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Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

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Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

Virtual Slide

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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中華民國比較病理學會第 49 次比較病理學研討會議程表

Schedule

49th Meeting of the Chinese Society of Comparative Pathology

時間99年 7 月 10 日(星期六) 0900~1600

地點國立臺灣大學獸醫學系 B01 演講廳

地址臺北市羅斯福路四段 1號

電話 02-33663858

Date July 10 2010 (Sat) 0900~1600

Location B01 School of Vet Med NTU

Address No 1 Sec 4 Roosevelt Road Taipei

Telephone 02-33663858

Time 時間 Schedule 議程 Moderator 主持

0830~0900 Registration 報到

0900~0910 Opening Ceremony 致詞

Dr CH Liu

劉振軒 理事長0910~1010 Keynote 專題演講

Blockade of AT1R modulates autoimmunity in the

chronic graft-versus-host disease model of lupus

nephritis

Dr SM Ka 賈淑敏 博士 National Defence Medical Center

國防醫學院醫學系病理學科

1010~1030 Coffee Break

1030~1100 Case 340病例討論

Dr YL Chen 陳燕麟 醫師 Department of Pathology Cardinal Tien Hospital

天主教耕莘醫院病理科

Dr FJ Leu

呂福江 主任 1100~1130

Case 341病例討論

Dr CW Shih 施洽雯 醫師 Department of Pathology Lotung Poh-Ai Hospital

羅東博愛醫院病理科

1130~1200 Case 342病例討論

Dr PR Wu 吳佩儒 醫師 Dept of Surgical Path Changhua Christian Hospital

彰化基督教醫院病理科 1200~1330 Lunch amp Board Meeting 午餐暨「中華民國比較病理學會理監事會議」

1330~1400 Case 343病例討論

YR Chen 陳盈妊 醫學生 Tzu Chi University amp Tzu Chi General Hosipital

佛教慈濟綜合醫院暨慈濟大學

Dr YH Hsu

許永祥 主任

1400~1430 Case 344病例討論

Dr JP Jhu 祝志平 醫師 Department of Pathology Lin Shin Hospital

林新醫院病理科

1430~1500 Case 345病例討論

Dr TT Huang 黃婷姿獸醫師 College of Vet Med National Chung-Hsing University

國立中興大學獸醫學院

1500~1530 Case 346病例討論

Dr TY Chan 詹德裕 獸醫師 School of Veterinary Medicine National Taiwan University

國立臺灣大學獸醫專業學院

1530~1600 General Discussion 綜合討論

3

Table of Contents (目錄)

A Schedule (議程表)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 2

B Table of Contents (目錄)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 3

C Case Signalment⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 4

D Case Diagnosis⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 5

E Keynote Speaker⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 6

F Comparative Pathology Case 340⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 7

Comparative Pathology Case 341⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 11

Comparative Pathology Case 342⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 16

Comparative Pathology Case 343⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 20

Comparative Pathology Case 344⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 23

Comparative Pathology Case 345⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 27

Comparative Pathology Case 346⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 32

G 中華民國比較病理學會數位式組織切片影像資料庫⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 35

H 1~49 次研討會病例分類表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 40

I 中華民國比較病理學會章程⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 59

J 會員資料更新服務⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 63

K 入會辦法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 64

L Map (國立臺灣大學獸醫專業學院)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 66

4

中華民國比較病理學會第 49 次比較病理學研討會

Case Signalment

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Signalment

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH 59- year-old man

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023 53-year-old woman

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A 59-year-old woman

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 47-year-old man

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 40-year-old woman

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Pheasant-tailed jacana

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32A3-to-4-year-old

mixed-breed dog

5

中華民國比較病理學會第 49 次比較病理學研討會

Case Diagnosis

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Diagnosis

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH

Mucinous-producing

urothelial-type

adenocarcinoma of

prostate

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023

Pulmonary placental

transmogrification

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A

Plexiform

fibromyxoma

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 Malignant epithelioid

trophoblastic tumor

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 Epithelioid sarcoma

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Acute carbofuran

intoxication

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32ATransmissible

venereal tumor

6

Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

Virtual Slide

http140112968382CSCP49CSCPcase3403709svs

User Name guest Password guest

Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

3

Table of Contents (目錄)

A Schedule (議程表)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 2

B Table of Contents (目錄)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 3

C Case Signalment⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 4

D Case Diagnosis⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 5

E Keynote Speaker⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 6

F Comparative Pathology Case 340⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 7

Comparative Pathology Case 341⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 11

Comparative Pathology Case 342⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 16

Comparative Pathology Case 343⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 20

Comparative Pathology Case 344⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 23

Comparative Pathology Case 345⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 27

Comparative Pathology Case 346⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 32

G 中華民國比較病理學會數位式組織切片影像資料庫⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 35

H 1~49 次研討會病例分類表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 40

I 中華民國比較病理學會章程⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 59

J 會員資料更新服務⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 63

K 入會辦法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 64

L Map (國立臺灣大學獸醫專業學院)⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ 66

4

中華民國比較病理學會第 49 次比較病理學研討會

Case Signalment

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Signalment

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH 59- year-old man

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023 53-year-old woman

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A 59-year-old woman

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 47-year-old man

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 40-year-old woman

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Pheasant-tailed jacana

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32A3-to-4-year-old

mixed-breed dog

5

中華民國比較病理學會第 49 次比較病理學研討會

Case Diagnosis

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Diagnosis

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH

Mucinous-producing

urothelial-type

adenocarcinoma of

prostate

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023

Pulmonary placental

transmogrification

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A

Plexiform

fibromyxoma

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 Malignant epithelioid

trophoblastic tumor

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 Epithelioid sarcoma

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Acute carbofuran

intoxication

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32ATransmissible

venereal tumor

6

Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

4

中華民國比較病理學會第 49 次比較病理學研討會

Case Signalment

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Signalment

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH 59- year-old man

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023 53-year-old woman

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A 59-year-old woman

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 47-year-old man

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 40-year-old woman

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Pheasant-tailed jacana

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32A3-to-4-year-old

mixed-breed dog

5

中華民國比較病理學會第 49 次比較病理學研討會

Case Diagnosis

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Diagnosis

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH

Mucinous-producing

urothelial-type

adenocarcinoma of

prostate

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023

Pulmonary placental

transmogrification

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A

Plexiform

fibromyxoma

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 Malignant epithelioid

trophoblastic tumor

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 Epithelioid sarcoma

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Acute carbofuran

intoxication

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32ATransmissible

venereal tumor

6

Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

5

中華民國比較病理學會第 49 次比較病理學研討會

Case Diagnosis

49th Meeting of the Chinese Society of Comparative Pathology

July 10th 2010

Case

No Presenter Institution Slide No Diagnosis

Case

340 Dr YL Chen

陳燕麟 醫師

Department of Pathology

Cardinal Tien Hospital

天主教耕莘醫院病理科 CTH

Mucinous-producing

urothelial-type

adenocarcinoma of

prostate

Case

341 Dr CW Shih

施洽雯 醫師

Department of Pathology

Lotung Poh-Ai Hospital

羅東博愛醫院病理科 LP-09-1023

Pulmonary placental

transmogrification

Case

342 Dr PR Wu

吳佩儒 醫師

Dept of Surgical Path

Changhua Christian Hospital

彰化基督教醫院病理科 10-12454A

Plexiform

fibromyxoma

Case

343 YR Chen

陳盈妊 醫學生

Tzu Chi University amp Tzu Chi

General Hosipital

佛教慈濟綜合醫院暨慈濟大

A2009-12 Malignant epithelioid

trophoblastic tumor

Case

344 Dr JP Jhu

祝志平 醫師

Department of Pathology

Lin Shin Hospital

林新醫院病理科 A10-1140 A1 Epithelioid sarcoma

Case

345 Dr TT Huang

黃婷姿 獸醫師

College of Vet Med

National Chung-Hsing

University

國立中興大學獸醫學院

CW09-039 Acute carbofuran

intoxication

Case

346 Dr TY Chan

詹德裕 獸醫師

School of Veterinary

Medicine National Taiwan

University

國立臺灣大學獸醫專業學院

NTU2010-32ATransmissible

venereal tumor

6

Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

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貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

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中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

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Keynote Speaker Chinese Society of Comparative Pathology July 2010

Ka SM Ka (賈淑敏) MS PhD

National Defence Medical Center 國防醫學院醫學系病理學科

Blockade of AT1R modulates autoimmunity in the chronic graft-versus-host disease model of

lupus nephritis

Although angiotensin (Ang) II mediates renal injuries via hemodynamic inflammatory andor

fibrogenic events there is little evidence for the beneficial effects of blocking of Ang on this

type of disease due to restoring of systemic immune dysfunction Autoimmune crescentic

glomerulonephritis (ACGN) is a variant of crescentic glomerulonephritis The outcome of

treatment of crescentic glomerulonephritis is poor We hypothesized that Ang II might be

subject to immunoregulation and thus ibersartan (IBT) an Ang II type 1 receptor blocker could

prevent the development of ACGN In the present study using an established ACGN model in

mice we treated the mice with 500 μgg body weight of IBT twice weekly for 2 months and

showed (1) suppression of T and B cell activation (2) a reduction in serum levels of

proinflammatory cytokines (3) improvement of proteinuria and renal dysfunction (4)

prevention of glomerular crescent formation renal interstitial inflammation and

glomerulosclerosis (5) a reduction in serum levels of autoantibodies and glomerular immune

deposits (6) prevention of T cell and macrophage infiltration of the kidney and (7) suppression

of fibrosis-related gene and protein expression in the kidney compared to ACGN (disease

control) mice Furthermore treatment of spleen cells from normal mice with IBT showed a

significant inhibition of proliferation compared to those without treatment of the drug

Based on these findings we propose that IBT exerts its preventive effects on ACGN through

modulation of systemic T cell activationproliferation and B cell activation as well as

suppression of mononuclear leukocyte infiltration locally in the kidney

Key words Lupus nephritis crescentic glomerulonephritis angiotensin-II receptor blocker

immunoregulating T cell B cell autoantibodies mononuclear leukocyte

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

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Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

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2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

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Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

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features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

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Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

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6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

7

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE HISTORY

Signalment 59-year-old man

Clinical History A 59-year-old man presented with urinary obstructive symptoms and

hematospermia on and off with serum PSA of 100 ngml Past medical history included

hypertension and peptic ulcer and benign prostate hypertrophy (BPH) The patient denied

alcohol consumption and smoking He underwent cystoscope and found a small white patchy in

urethra near bladder neck and unremarkable finding in bladder The pathology report showed

cystitis gladularis 7 months later because the patient had persistent obstructive symptoms

and gross hematuria trans-rectal ultrasound of the prostate was done and showed prostate

tumor of unknown origin In the meanwhile mucus-urine was also noted His serum PSA and

free PSA are of 167 ngml and 023 ngml with the trans-urethral resection biopsy report

showed PSA-negative mucin-producing adenocarcinoma of unknown origin favored colon

metastasis Colonscope was done and showed 2 non-neoplastic colonic polyps Cystoscope

showed prostatic urethral tumor and unremarkable bladder finding Other tumor surveys

included whole abdomen CT and MRI showed prostate tumor of unknown primary or metastasis

with seminal vesicle obstruction bone scan and positron emission tomography (PET) showed no

other lesions except prostate The patient received trans-urethral resection of prostate (TURP)

to relieve his obstructive symptoms The patient has no sign of recurrence with 6 months follow

up

Laboratory Results

CBCDC WNL

Biochemistry (sugar Ca BUN Cr Na K Cl AST ALT) WNL

PSA 167 ngml and 023 ngml

Gross Findings The TURP specimen submitted consisted of multiple pieces of soft tissue

fragment measuring 5 gm in weight Grossly they showed brown in color and firm in

consistency

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

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E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

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通訊

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中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

8

Case Number 340 Chinese Society of Comparative Pathology July 2010

Chen Yen-Lin (陳燕麟) MD Suen Jeng-Hung (孫政宏) MD Leu Fur-Jiang (呂福江) MD

PhD 江蓉華 林進耀 蕭博仁

Department of Pathology Cardinal Tien Hospital (天主教耕莘醫院病理科) CASE RESULT

Histopathological Finding Microscopically the sections show picture of adenocarcinoma with

copious mucin production forming mucin pools in some areas The neoplastic glands are

arranged in a cribriform glandular and villous adenoma-like pattern in different areas Tumor

cells were columnar with high nuclear to cytoplasmic ratio marked pleomorphism and no

nucleoli There was no signet-ring cell necrosis urethritis gladularis intraurothelial neoplasia

or adenocarcinoma in situ Lymphovascular and neural invasion were not identified in the

sections

Virtual Slide

http140112968382CSCP49CSCPcase3403709svs

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Immnohistochemical Stains The immunohistochemical profile showed totally negative for PSA

PSAM and AMACR Diffuse positive stain for CK7 CK20 CEA (monoclonal) and focal positive

for HMWK and CDX2 in tumor cells

Diagnosis Prostate TURP - Mucinous-producing urothelial-type adenocarcinoma of prostate

Discussion Mucinous-producing urothelial-type adenocarcinoma of the prostate is first

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

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E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

9

described by Tran and Epstein in 1996 It is a rare carcinoma which has only 20 cases reported

in the English literature The origin of this carcinoma is from prostatic urethra or prostatic

gland with urothelial metaplasia Mucinous-producing urothelial-type adenocarcinoma of the

prostate may arise from malignant transformation of urethritis glandularis but about 13 of the

cases could not be identified This is because of either sampling issues or destruction by the

growing massClinical manifestation of mucinous-producing urothelial-type adenocarcinoma of

the prostate included non specific obstruction symptoms A more specific finding in this rare

carcinoma is mucusuria About 20 of the cases can be seen in the report of Tran et al PSA

usually is not elevated but occasionally can be seen elevation

Microscopically it is identical to bladder urothelial adenocarcinoma which shows atypical

columnar epithelium with large mucin lake Mucin pools (100) villous features (47)

necrosis (133) and signet ring cells (20) can be also noted As urothelial-type

adenocarcinoma of prostate is not usual prostate acinar adenocarcinoma they should not be

assigned a Gleason grade

The main differential diagnosis included 1 prostate conventional mucinous acinar

adenocarcinoma 2 metastatic bladder adenocarcinoma 3 metastatic seminal vesicle

adenocarcinoma 4 metastatic colonic adenocarcinoma Prostate conventional mucinous acinar

adenocarcinoma is rare and about 02 of all prostatic carcinoma Microscopically shows

cuboidal epithelium and cribriform glands with mucin pool Metastatic colonic adenocarcinoma

is the most difficult differential diagnosis It is very similar in HampE stain

Immunohistochemistry can be a great help in differential diagnosis Metastatic bladder

adenocarcinoma is also hard to distinguish by HampE stain It arises from bladder urothelium

which is the only difference from mucinous-producing urothelial-type adenocarcinoma of the

prostate Therefore it is necessary to exclude bladder primary by either cystoscope or other

clinical tools Metastatic seminal vesicle adenocarcinoma shows variable pattern with typical

papillary pattern to solid sheets

Immunohistochemical stain can provide a great help in differential diagnosis Prostate marker

PSA

PSMA

P504s

Urothelium marker

CK7

CK34βE12

Colon marker

CK20

CEA

CDX2

Prostate mucinous acinar

adenocarcinoma

(+) (-) (-)

Metastatic colonic adenocarcinoma (-) (-) (+)

urothelial-type adenocarcinoma of the

prostate

(-) (+) (-+)

The prognosis of mucinous-producing urothelial-type adenocarcinoma of the prostate is more

aggressive About 533 of cases die of disease (mean 492 months) etastatic sites included

10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

Virtual Slide

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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10

lungs liver pelvic side wall and testis Hormone therapy is not appropriate in

mucinous-producing urothelial-type adenocarcinoma of the prostate

Reference 1 Tran KP and JI Epstein Mucinous adenocarcinoma of urinary bladder type arising from the prostatic urethra

Distinction from mucinous adenocarcinoma of the prostate Am J Surg Pathol 1996 20(11) p 1346-50

2 Ortiz-Rey JA et al Mucinous urothelial-type adenocarcinoma of the prostate Scand J Urol Nephrol 2004

38(3) p 256-7

3 Curtis MW AJ Evans and JR Srigley Mucin-producing urothelial-type adenocarcinoma of prostate report

of two cases of a rare and diagnostically challenging entity Mod Pathol 2005 18(4) p 585-90

4 Adley BP et al Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal

adenocarcinoma Int Braz J Urol 2006 32(6) p 681-7 discussion 687-8

5 Niu H et al Mucin-producing urothelial-type adenocarcinoma of the prostate (a case report and review of the

literature) Chinese Journal of Clinical Oncology 2006 3(5) p 370-372

6 Osunkoya AO and JI Epstein Primary mucin-producing urothelial-type adenocarcinoma of prostate report

of 15 cases Am J Surg Pathol 2007 31(9) p 1323-9

7 Raspollini MR et al Immunohistochemistry in the differential diagnosis between primary and secondary

intestinal adenocarcinoma of the urinary bladder Appl Immunohistochem Mol Morphol 2005 13(4) p

358-62

11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

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2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

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席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

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11

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE HISTORY

Signalment 53-year-old woman

Clinical History The 53 year old female was quite well in the past except uterine myoma sp

operation 7 years ago She suffered from traffic accident with large laceration wound of left

lower leg on 98-01-05 and was repaired by our Orthopedic Doctor At the same time left lower

lung nodule was noted by computed tomographic scan (CT scan) The lung nodule measuring

20 x 17 cm She did not complain of any respiratory or systemic symptoms Her prior medical

and familial history was unremarkable Under the impression of RO malignancy she was

admitted for further evaluation and management Whole body bone scan was performed on

98-02-06 and showed negative finding The pulmonary function test was performed on

98-02-06 and revealed FEV1 208 L (95 Pred) VATS wedge resection of LLL for histological

conformation of nodule was performed on 98-02-09

Clinical Pathology

RBC 386x106uL (0-5 x106uL) Hb 117 gmdL (120-160 gmdL) Hct 349 (37-47)

WBC 5100uL (4500-11000uL) Plt 244 x104dL (15-40 x104dL) Lymphocyte 423

(200-450) Neutrophil 484 (450-750) Monocyte70 (00-90) Eosinophil18

(10-30) Basophil05 (00-10) BUN11 mgdL (7-22 mgdL) Creatinine06 mgdL

(06-13 mgdL) Glucose100 mgdL (70-110 mgdL) AST 21 UL (5-40 UL) ALT 17 UL (5-40

UL) Na1389 mmolL (133-145 mmolL) K34 mmolL (33-51 mmolL)

Gross Findings Grossly the wedge resected lung showed a well defined tumor measuring 20 x

17 x 12 cm reddish-brown in color and soft in consistency Cut sections of the tumor showed

some grape-like structures No hemorrhage or necrosis is noted

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

12

Case Number 341 Chinese Society of Comparative Pathology July 2010

Shih CW (施洽雯) MD MS Chen CT (陳朱德) MD

Department of Pathology Lotung Poh-Ai Hospital (羅東博愛醫院病理科) CASE RESULT

Histopathologic Findings Histologically the tumor is composed of villous structures

resembling placental villi and surrounded by hyperinflated air spaces At higher magnification

these villous structures corresponded to alveolar walls enlarged by mature adipose tissue and

fibroblasts intermixed with thin or dilated capillaries No smooth-muscle cartilage bronchial

structures were present in these villous structures These villous structures were lined either

by flattened type alveolar cells or by hyperplastic type pneumonocytes Anthracosis was noted

in areas The adjacent lung was normal or mild emphysematous change

Virtual Slide

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Immunohistochemistry Immunohistochemical stain was performed The epithelia lining the

villous structures were positive for TTF1 CK(HMW) CK7 focal positive for Ki67 and negative

for smooth muscle actin CD34 and calretinin The cores of the villous structures were positive

for smooth muscle actin and CD34 and negative for TTF1 CK(HMW) CK7 calretinin and

TTF1

Differential Diagnosis

1 Intralobar pulmonary sequestration

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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校園出入口

13

2 Congenital cystic adenomatoid malformation

3 Cystic lung disease

4 Emphysema

5 Pulmonary placental transmogrification

6 Metastatic trophoblastic disease

Diagnosis Pulmonary placental transmogrification

Comments Pulmonary placental transmogrification (PPT) also called placentoid bullous lesion

is an unusual condition first described in 1979 It is a peculiar histologic pattern characterized

by formation of placental villuslike structures in the lung parenchyma PPT has been described

in patients with severe emphysema associated with cigarette smoking congenital bullous

emphysema and fibrochondromatous hamartomas of the lung To date fewer than 20 cases

have been reported in the literature PPT occurs predominantly in males (MF-135) in the

second to fifth decade of life (mean-4452 years median-50 years)

The presentation of PPT ranges from asymptomatic to clinically overt and is associated with

other pulmonary diseases such as chronic obstructive airway disease repeated pneumothorax

bronchopneumonia and even respiratory distress The lesions are occasionally incidental

masses seen by radiography

PPT is not only associated with cystic or emphysematous lesions but also with hamartomatous

conditions Hence there is some controversy regarding its pathogenesis ie whether this lesion

is a reactive change or neoplastic one The villous appearance of these pulmonary tissues

probably results from the development of edema and fibrosis in the residual strands of alveolar

tissue present in the enlarged airspaces of emphysema PPT has also been reported to be a

benign proliferation of immature interstitial clear cells with secondary cystic change The

predominant component of the papillary projection is fibroadipose stroma which is notably

immature in some cases The presence of adipose tissue in patients with emphysema and PPT

may be the result of metaplastic mesenchymal differentiation The possibility that hamartomas

is arised from a mesenchymal stem cell which is involved in the formation of hamartoma or

plays a role in PPT Hypotheses of pathogenesis also include a lymphatic or vascular

proliferation in emphysematous lung parenchyma

The macroscopic appearance was similar in most cases consisting of a tanwhite rubbery

bulging and irregular mass without cystic change or hemorrhage Most of the tumors had

well-circumscribed borders Infrequently papillary projections within hamartomas could be

seen grossly resulting in a granular cut surface Grossly PPT mimics spongy or cystic lung

lesions such as congenital cystic adenomatoid malformation and mucinous cystic tumour of the

lung But these lesions are mucin rich and most often affect infants and children

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

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65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

14

Microscopically PPTs were to varying degrees composed of myxoid or edematous stroma In

most cases prominent epithelial foldings formed the papillary projections reminiscent of

immature placental villi The stroma contained fibroadipose tissue and blood vessels and

inflammatory cells (ie macrophage and lymphocytes) diffusely dispersed In a few cases

spindled cells were identified in the immature stroma The lining epithelium consisted of either

nonciliated flat and cuboidal or ciliated columnar cells and mixed types The admixture of

various tissue elements with an epithelial covering on the outer surface mimics a placental

villous It seems reminiscent of a hamartoma a common benign tumour originating from

primitive mesenchyme having fibrochondromatous elements But both the primitive

mesenchyme and fibrochondromatous elements are absent in PPT

Immunohistochemical analyses revealed that a major portion of the lining epithelium of PPT

was positive for TTF-1 and focally epithelial cells were also stained with anti-Ki-67 antibody

indicating that the epithelium was of lung origin and proliferating In contrast very few stromal

cells were positive for these two markers Conversely many stromal cells especially the

spindled cells were immunoreactive for c-Kit a stem cell or mast cell marker Further study

with stain for naphthol-ASD-chloroacetate esterase demonstrated that the c-Kit-positive cells

were mast cells and not stem cells

The high-resolution CT of PPT shows a well-defined nodule with air fat and sot tissue

components The radiologic differential diagnosis of the lesion should include lesions with fatty

components and lesions containing air Fat is present in lipomas and hamartomas The

presence of air in a nodule may result from cavitation that can occur in both benign and

malignant nodules PPT needs to be clinically differentiated from overexpanasion from

segmental bronchial atresia air trapping by a partially obstructing intrabronchial mass

idiopathic giant bullous emphysema and cystic adenomatoid malformations especially in

younger patients

In spite of the fact that not so many cases have been reported in literatures all reported cases

have done well after surgery Untreated placental transmogrification of the lung can lead to

severe pulmonary symptoms

In conclusion PPT is a unique pulmonary lesion showing morphological similarities to the

placental villi on microscopic examination It can be associated with a cystic emphysematous

lesion and other hamartomatous conditions Awareness of this rare entity of PPT early

diagnosis and appropriate treatment of the lesion can be curative

References

1 McChesney T Placental transmogrification of the lung a unique case with remarkable histopathologic

15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

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獸醫三館

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15

features Lab Invest 1979 40 245-6

2 Fidler ME Koomen M Sebek B Greco MA Rizk CC Askin FBPlacental transmogrification of the lung a

histologic variant of giantbullous emphysema Clinicopathological study of three further cases Am J Surg

Pathol 1995 19 563-70

3 Horsley WS Gal AA Mansour KA Unilateral gaint bullous emphysema with placental transmogrification of

the lung Ann Thoracic Surg 1997 64 226-8

4 Kronz JD Palmer C Askin FB Placental transmogrification of the lung Arch Pathol Lab Med 1999 123 856

5 Ferretti GR Kocier M Moro-Sibilot D Brichon PY Lantuejoul S Placental transmogrification of the lung CT

pathologic correlation of a rare pulmonary nodule Am J Roentgenol 2004 183 99-101

6 Xu R Murray M Jagirdar J Delgado Y Melamed J Placental transmogrification of the lung is a histologic

pattern frequently associated with pulmonary fibrochondromatous hamartoma Arch Pathol Lab Med 2002

126 562-6

7 Cavazza A Lantuejoul S Sartori G Bigiani N Maiorana A Pasquinelli G et al Placental transmogrification of

the lung clinicopathologic immunohistochemical and molecular study of two cases with particular emphasis

on the interstitial clear cells Hum Pathol 2004 35 517-21

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

Virtual Slide

http140112968382CSCP49CSCPcase3423706svs

User Name guest Password guest

Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

Virtual Slide

http140112968382CSCP49CSCPcase3433704svs

User Name guest Password guest

Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

16

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE HISTORY

Signalment59-year-old woman

Clinical HistoryThe patient is a 59-year-old Minnan Taiwanese woman a homemaker with a

history of hypertension She had acid regurgitation for a long time She received panendoscopy

on 82609 and showed reflux esophagitis LA Gr A and a gastric submucosal tumor

Endoscopic ultrasound examination was done on 92509 and showed a 2 cm well-defined

submucosal tumor lesion at the gastric antrum It was hypoechoic with mild heterogeneous

echogenicity without cystic lesion calcification or septum Gastrointestinal mesenchymal tumor

was suspected The patient then accepted the surgical treatment

Clinical Pathology

WBC 86x103μL(35-91 x103μL) RBC 457x106μL(38-49 x106μL) Hb 140

gdL(120-150) Hct 412(350-440) MCV 902 fL(838-980 fL) MCH 306 pg(284-338

pg) MCHC 340 gdL(334-352 gdL) Platelet 345 x103μL(157-377 x103μL) RDW

120(117-149) Neutrophil-Seg 604(394-726) Lymphocyte 320(21-51)

Monocyte 51(460-110) Eosinophil 15(04-76) Basophil 10(lt13) GPT

19UL(11-40UL) Urea Nitrogen 13 Creatinine 060 mgdL(04-10 mgdL) Na 140

mmolL(136-144 mmolL) K 34 mmolL (36-51 mmolL) Glucose(Random) 106 mgdL

(70-110 mgdL) PT 102 sec (99-120 sec)

Gross FindingsThe specimen submitted consisted of two gastric tissue fragments measuring

up to 87x55x08 cm in size in fresh state One gastric tissue fragment with tumor consisted of

a duodenal cuff measuring 25 cm in length There was a submucosal tumor at the antrum of

stomach in one gastric tissue fragment On cut the submucosal tumor measured 2x12x12 cm

in size It was solid fleshy and elastic with gelatinous appearance The proximal and distal

margins measured 22 cm and 21 cm in length respectively Another gastric tissue fragment

was unremarkable

17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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17

Case Number 342 Chinese Society of Comparative Pathology July 2010

Wu PR (吳佩儒) MD Hsu HT (許惠婷) MD Chen CJ (陳志榮) MD Yeh QT (葉坤土)

MD

Department of Surgical Pathology Changhua Christian Hospital (彰化基督教醫院病理科)

CASE RESULT

Histopathologic FindingsMicroscopically it showed a picture of gastric stromal tumor with a

plexiform and multinodular involvement within submucosa and muscularis propria The tumor

cells were composed of hyppocellular bland-looking spindle cells within a fibrocollagenous to

myxoid stroma containing arborizing vessels No necrosis was seen No mitotic figure was

found

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Immunohistochemistry The tumor cells showed CD117(-) CD34(-) S-100 protein(-) ALK-1(-)

DOG1(-) HMB45(-) EMA(-) beta-catenin(plusmn) CD56(-) and desmin(+ focal) by

immunohistochemical studies

Differential Diagnosis

1 Gastrointestinal stromal tumor

2 Leiomyoma

3 Schwannoma

4 Neurofibroma

5 Fibromatosis

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

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Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

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通訊地址

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64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

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蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

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會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

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審核結果

66

獸醫三館

校園出入口

18

6 Inflammatory fibroid tumor

7 Perineuroma

8 Plexiform fibromyxoma

DiagnosisPlexiform fibromyxoma

DiscussionPlexiform fibromyxoma is a recently described new entity of gastric mesenchymal

tumor Herein we present a rare and new entity which is distinct from the GIST Gastric

mesenchymal tumor with myxoid features has been reported in the previous literature with

variable terminology such as myxoma and fibromyxoma The term ldquoplexiform angiomyxoid

myofibroblstic tumor of the stomachrdquo has been used in recent years

The tumor is rare According to the estimation by Miettinen et al the ratio of GIST to plexiform

fibromyxoma is more than 1501 To our best knowledge about 22 cases had been reported up

to now

Most patients with plexiform fibromyxoma are young and middle aged adults The number of

men and women is roughly equal Tumor size ranges from 19 cm to 15 cm (median size of 55

cm) The tumor location seems to be exclusive in the gastric antrum especially the pyloric

region It is common that tumor extends into the duodenal bulb wall or exterior surface of

stomach and proximal Patients usually present with upper gastrointestinal bleeding gastric

ulcer dyspepsia abdominal mass and weight loss Some patients present without clinical

symptom with incidental finding

Grossly the tumors locate variably at intraluminal intramural with externally bulging The cut

surfaces are pale tan mucoid gelatinous or hemorrhagic

Histologically the tumor cells characterize by a plexiform and multinodular growth pattern

with involvement of the gastric muscularis propria An infiltrative margin to the mucosa or the

muscularis propria is often seen The nodules are composed of bland-looking spindled to ovoid

cells in a myxoid or fibromyxoid stroma A prominent capillary network with chicken-wire

appearance is often found Some tumor cells show intravascular involvement There is no

tumor necrosis calcification nuclear palisades or skenoid fibers Cytologically the tumor cells

show indistinct cytoplasm and cellular borders The nuclei are oval with peppered chromatin

and a delicate nucleolus No or rare nuclear atypia is found Mitotic activity is low (lt150 to

450 HPF median 150 HPF)

The myxoid matrix shows negative staining for alcian blue-positive (at pH 25) and periodic

acid-Schiff Immunohistochemically the tumor cells show positive for SMA and CD10 (variable)

and negative for KIT DOG1 CD34 desmin S100 protein CK and heavy caldesmon KIT and

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

Virtual Slide

http140112968382CSCP49CSCPcase3433704svs

User Name guest Password guest

Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

http140112968382CSCP49CSCPcase3443705svs

User Name guest Password guest

Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

19

PDGFRA mutations show wild-type sequences

Up to now the tumorigenesis is still uncertain Immunohistochemically the tumor cells show

SMA(+) desmin(-) and caldesmon(-) No skeinoid fiber is found under electronic microscope

The above features may demonstrate the myofibroblastic origin rather than smooth muscle

origin However small number of tumor cells show positive for smooth muscle marker It may

demonstrate that some tumor cells owing the ability to differentiate to smooth muscle cells

It seems to be a benign tumor in more than 20 years follow-up according to the study of

Miettinen et al No obvious cancer-death or metastasis is found However the cases number is

still low Complete excision and follow-up are recommended More further studies about the

tumor in clinical and molecular level are needed

Reference 1 Miettinen M Makhlouf HR Sobin LH Lasota J Plexiform fibromyxoma a distinctive benign gastric antral

neoplasm not to be confused with a myxoid GIST Am J Surg Pathol 2009 Nov33(11)1624-32

2 Wang WY Li JN Li GD Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus successful

diagnosis and treatment by endoscopy J Clin Pathol 2010 Jun63(6)569-70

3 Rau TT Hartmann A Dietmaier W Schmitz J Hohenberger W Hofstaedter F Katenkamp K Plexiform

angiomyxoid myofibroblastic tumour differential diagnosis of gastrointestinal stromal tumour in the stomach

J Clin Pathol 2008 Oct61(10)1136-7

4 Takahashi Y Shimizu S Ishida T Aita K Toida S Fukusato T Mori S Plexiform angiomyxoid myofibroblastic

tumor of the stomach Am J Surg Pathol 2007 May31(5)724-8

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

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Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

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E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

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三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

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電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

20

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 47-year-old man

Clinical History The 47-year-old man was generally healthy in the past In 200410 multiple

palpable tender right lower neck and supraclavicular lymph nodes were noted He thus went to

台中中山醫院 and chest X-ray showed RUL bulging soft tissue and widening upper

mediastinum One month later exertional dyspnea appeared No cough no body weight loss or

poor appetite accompanied The image-guided LN biopsy showed metastatic poorly

differentiated carcinoma with unknown origin Whole body PET CT showed multiple

enlarged LNs in bilateral lower neck and thoracic inlet He has received cisplatin+5-FU

chemotherapy but not good tumor response As time goes by SVC syndrome with facial

swelling gradually appeared and pancytopenia and neutropenic fever occurred Stomatitis

dysphagea general weakness followd by Dyspnea aggrevated thus the first time thoracentesis

was performed in 20059 with reddish (RBC 32750 μl) and turbid pleural effusion without TB

bacteria or fungus Two course chemotherapy (CHOP) with Irresa started in 20061 at 台中榮總

醫院 However bilateral neck mass enlarged and CXR showed upper mediastinum widening

Diseased progressed The dyspnea aggrevated again and CXR showed Rt side massive pleural

effusion thus the second time thoracentesis was performed with bloody pleural effusion He

didnrsquot receive chemotherpapy againDNR was signed on 2006731 The patient was expired on

200683

Clinical Pathology

200411 β-HCG 441 AFP 1015 Ca-125 322 CA19-9 615

200510 β-HCG 788 Ca-125 460 CA19-9 3957

20063~5 β-HCG 1304 4545 8946 AFP 1015 Ca-125 844 986 2357 CA19-9 7242

2732 3816

Gross Findings At autopsy the main lesion was located in anterior mediastinum measuring

6times4times3 in size In addition this tumor was also directly involved right pleural space mimicking

malignant mesothelioma No other organs metastasis was found

21

Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

Virtual Slide

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User Name guest Password guest

Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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User Name guest Password guest

Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

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39

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40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

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Case Number 343 Chinese Society of Comparative Pathology July 2010

Chen YR (陳盈妊) MD Student Hsu Yung-Hsiang (許永祥) MD

Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopathological Findings the main tumor is composed of polygonal cells with eosinophilic or

clear cytoplasm and multinuclear giant cells accompanied capillary stroma and focal papillary

growth

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Immunohistochemistry CK7(+) CK20(+) CD10 (+) EMA (+) calretinin(-) CEA(-) TTF-1(-)

P63(-) β-HCG(+) amp PLAP (+) CD30 (-) hPL(-) Hepa-1(-) and Glypican 3(-)

Differential Diagnosis

1 Hepatoid carcinoma of thymus

2 Renal cell carcinoma metastatic

3 Psendomesotheliomatous adenocarcinoma of lung

4 Choriocarcinoma

5 Malignant epithelioid trophoblastic tumor

Diagnosis Malignant epithelioid trophoblastic tumor

22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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66

獸醫三館

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22

Discussion The histopathologic picture of the main tumor is composed of polygonal or

epithelioid like cells with clear or eosinophilic cytoplasm containing vacuoles prominent

eosinophilic nucleoli and plenty of capillary stroma Some multinuclear giant cells mimicking

syncytiotrophoblasts containing vacuoles are also noted Immunohistochemisty stain shows

prominent Ck7 amp Ck 20 positive in both cells

According to clinical laboratory data with high β-HCG so immunohistochemistry stain is

performed using anti-β HCG antibody Only syncytiotrophoblast like cells are positive but

monotonous like cells are negative

In addition EMA amp CD10 are also strong positive in both cells Above the results trophoblast

malignancy is diagnostic In this case the main monomorphic tumor cells is mimicking

intermediate trophoblastic cells Unfortunately the hPL stain is negative

But we strong suggest this rare tumor is diagnosed as malignant epithelioid trophoblastic

tumor according to histologic picture and clinical with moderate elevated of β-HCG Review

the article this case may be the first case in the mediastinum

Reference 1 Moran CA Suster S Primary mediastinal choriocarcinomas a clinicopathologic and immunohistochemical

study of eight cases Am J Surg Pathol 1997211007- 12

2 Shih IM Kurman RJ Epithelioid trophoblastic tumor a neoplasm distinct from choriocarcinoma and placental

site trophoblastic tumor simulating carcinoma Am J Surg Pathol 1998221393- 403

23

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

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第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

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部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

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Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE HISTORY

Signalment 40-year-old woman

Clinical History A 40 year old female suffered from an irregular nodule (3 x 2 cm) in right hip

tumor for a month The tumor increased size rapidly The tumor was wide excised (suspect

melanoma) 41 x 36 x 12 cm and were sent for pathological examination ( Grossly there

is a tumor below the skin and measures 18 x 06 x 06 cm Sections A1-3 were taken for

diagnosis

24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

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Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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24

Case Number 344 Chinese Society of Comparative Pathology July 2010

1JP Jhu (祝志平) MD 2Yung-Hsiang Hsu (許永祥) MD 1Department of Pathology Lin Shin Hospital (林新醫院病理科) 2Buddhist Tzu-Chi General Hospital and Tzu-Chi University (佛教慈濟綜合醫院暨慈濟大學)

CASE RESULT

Histopatholgy Ill-defined lesion in the subcutis and is composed of compactly-arrayed tumor

cell nests in the peripheral areas and contains marked central necrosis

Mitosis is found

Virtual Slide

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User Name guest Password guest

Immunohistochemistry surveys

1 CK Vimentin and EMA (+)

2 Smooth muscle actin HMB-45 (-)

Differential Diagnosis

1 Infectious or necrotizing granuloma CK (-)

2 Nodular fasciitis Fibrohistiocytoma Fibromatosis No epithelioid features and CK (-)

3 Malignant melanoma more pleomorphism S-100 (+) HMA-45 (+) CK (-)

4 Synovial sarcoma Location no dermal involvement and ulceration

Diagnosis Skin and subcutis hip right excision showing epithelioid sarcoma

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

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Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

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39

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40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

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會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

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中華民國比較病理學會

申請人 簽章

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審核結果

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獸醫三館

校園出入口

25

Diagnostic Criteria

Low power

1 Ill-defined multinodular firm mass with necrotic foci

2 Usualy less 5 cm

3 Diffuse infiltrative margins

4 Nodules of monomorphic eosinophilic epithelioid to spindle-shaped cells

5 Dense fibrous stroma

High power

6 Minimal nuclear pleomorphism

7 Mitoses (varibale)

8 Central necrosis or myxohyaline degneration

9 Perineural and vascular invasion

10 Cytoplasmic vacuolation (variable0

11 Chondroid or osseous metaplasia (rare)

Immunophenotype

1 CK EMA Vimentin (+)

2 S-100 (+-)

3 Desmin (-) CD34 50 (-)

4 Keratin 8(K8) 94 (+) K19 72 34 bEH12 48 K7 22

Discussion Epithelioid sarcoma (ES) was first described by Laskowski in 1961 and Enzinger

reported 62 cases and coined the term ES ES is the most common primary sarcoma of the hand

and wrist (distal extremities) A history of trauma is elicited in about 20 - 25 of caes ES has

been reported in almost all ages but is most prevalent in patients between 10 and 39 years of

age usually in the adolescents and adults with a male predominence ES arising in the dermis

often presents as a painlees slow-growing superficial mass ES in the subcutis or fascial tissue

presents as fixed hard nodule Skin ulceration is common Tumor spreads along the fascia

planes or neurovascular bundles Radical surgery is the treatment of choice but slow relentless

course with multiple local recurrence and eventual metastasis and death despite treatment

happened Fifty per cent of ES metastasize to lymph nodes lung and soft tissues Tumor less

than 5 cm has a better prognosis ES is characterized by a predominantly nodular growth

pattern of epithelioid and plump spindled cells Necrosis hemorrhage cyst formation focal

calcification or myxohyaline stroma replacing the tumor cells are commonly found in the center

of the ES Nodules of monomorphic eosinophilic epithelioid to spindled cells are found at the

periphery of tumorsThe mitotic rate in ES varies but is usually lt 10 mitoses 10 HPF

Coexpression of CK and vimentin is the charateristic immunoprofile in ES If questions about

the diagnosis arise a second opinion should be sought from an expert in sarcoma pathology

Whenever possible tissue should be frozen for potential molecular diagnosis and additional

tissue banked for research

26

References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

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中華民國比較病理學會

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References 1 Barnound R Collardeau-Frachon S Thomason V Lung metastasis of epithelioid sarcoma revealed by bilateral

spontaneous pneumothorax a pathological diagnosis Ann Pathol 2010 30 139-42

2 Mastrangelo G Fadda E Cegolon L etc A European project on incidence treatment and outcome of sarcoma

BMC Public Health 2010 10 188

3 Collin T Blackburn AV Milner RH Sarcomas in the groin and inguinal canalmdashoften missed and diffficult to

manage Ann R Coll Surg Engl 2010 92 326-9

4 Rekhi B Folpe AL Deshmukh M etc Sclerosing epithelioid fibrosarcoma- A report of two cases with cytogenetic

analysis of FUS gene rearrangement by FISH technique Pathol Oncol Res 2010

5 Hasegawa T Molecular pathological diagnosis of soft tissue tumors Rinsho Byori 2010 58 371-81

6 Jain S Xu R Prieto VG etc Molecular classification of soft tissue sarcomas and its clinical applications Int J

Clin Exp Pathol 2010 3 416-28

7 Thway K Fisher C Histopathological diagnostic discrepancies in soft tissue tumors referred to a special center

Sarcoma 20092009 741975 1-7

8 Zhang P Brooks JS Modern pathological evaluation of soft tissue sarcoma specimens and its potential role in

soft tissue sarcoma research Curr Treat Options Oncol 20045 441-50

9 Collin F Gelly-Marty M Coindra JM etc Soft tissue sarcoma current data in the field of pathlogy Cancer

Radiother 2006 10 7-14

10 de Alava E Molecular pathology in sarcomas Clin Transl Oncolo 2007 9 130-44

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

http140112968382CSCP49CSCPcase3453710svs

User Name guest Password guest

Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

27

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE HISTORY

Signalment Pheasant-tailed jacana age unknown

Case History Pheasant-tailed jacana (Hydrophasianus chirurgus) is one of the endemic avian species in Taiwan Numerous pheasant-tailed jacanas were found dead at the paddy filed of

conservation area in Guan-tian Township Tainan County during Dec 2009 Dead birds

including 8 pheasant-tailed jacana 1 painted snipe 2 moorhens 2 green-winged teals 1

red-collared dove and 4 tree sparrows were collected and frozen by Endemic Species Research

Institute The bodies were sent to the Animal Disease Diagnostic Center National Chung Hsing

University for disease diagnosis

Gross Finings Dead birds were thawed at room temperature prior to necropsy At necropsy the

birds seemed healthy with normal state but crops esophagus and gizzard filled with undigested

rice grains Livers and lungs were congested No significant gross lesion was observed in kidney

spleen and other organs The organs were fixed by 10 formalin for histopathological

examination

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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------------------------------中華民國比較病理學會----------------------------

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入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

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(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

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中華民國比較病理學會入會申請及會員卡 會籍電腦編號

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獸醫三館

校園出入口

28

Case Number 345 Chinese Society of Comparative Pathology July 2010

1Huang TT (黃婷姿) DVM 2Hsu WY(許為云) DVM 2Chan FT (詹芳澤) DVM 2Wang LM

(王齡敏) DVM MS 4Lin PT (林佩羿) DVM MS 1Wu CH(吳介豪) DVM 1Yu KJ (余國睿)

DVM 2Shien JH (沈瑞鴻) DVM PhD 3Chang WF (張文發) DVM MS 14Liao JW(廖俊旺)

DVM PhD

1Graduate Institute of Veterinary Pathology 2Department of Veterinary Medicine 3Animal

Disease Diagnostic Center National Chung Hsing University (中興大學獸醫病理生物學研究

所獸醫學系動物疾病診斷中心) 4Endemic Species Research Institute (特有生物保育研究中心)

CASE RESULT

Microscopic Findings Non specific lesion but hearts and lungs showed marked congestion An

increase of the mucus secretion also presented in the esophagus and trachea even the

bronchioles of lungs No significant lesion but slight postmortem change was observed in the

other examined organs

Virtual Slide

http140112968382CSCP49CSCPcase3453710svs

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Laboratory Examination

Microbiologic examination No bacteria were isolated from the hearts and livers which

cultured by the blood and MaConkey agars

Molecular biological examination The RT-PCR method was conducted for the suspected

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

29

viral infection in the brains and lungs of the birds The result proved negative

Brain acetyl cholinesterase (AChE) activity Determination of brain AChE activity brain

homogenates were analyzed by enzymatic methods using an automatic analyzer (Chiron

Diagnostics Corporation Oberlin OH USA) Results revealed that activity of brain AChE

was inhibited by 891plusmn21 in dead birds (remained 42plusmn81 UL n = 5) when compared

with normal hens (3907plusmn274 UL n = 3)

Pesticide analysis Five specimens including rice grains obtained from crop and gizzard

contents were submitted to Technical Service Center National Animal Industry Foundation

for pesticide analysis Results expressed that mainly detecting peak was carbofuran and

some of minimal other pesticides included oxamyl deltamethrin carbendazim imidacloprid

and prochloraz were accompanied analysis by the multiresidue of pesticide analysis High

concentrations and main residues of carbofuran were ranged from 57 to 368 ppm in the

specimens

Diagnosis Acute carbofuran intoxication of pheasant-tailed jacana in paddy field

Discussion Hydrophasianus chirurgus is a member of jacanidae they change feathers during

migration polyandry summer and winter seasons (Chen et al 2008) Pheasant-tailed jacana

prefers to live in the wetlands with floating-leaved planet such as water caltrop and lily The

body weight of female pheasant-tailed jacana is about 190-250 g and the male weights about

120-150 g females are heavier than males Pheasant-tailed jacana has unique feet that are

very long and enabling them to walk on floating-leaved vegetation (翁 1999) Unfortunately lot

of Pheasant-tailed jacana was incidentally found dead in this event

Endemic death of wild animals may cause by numerous infectious diseases such as avian

influenza Newcastle disease etc In this case no infectious pathogens were proved Based on

the history microbiology molecular biology and pathological examinations poisoning was

suspected to cause death in a colony of wild animals High levels of carbofuran range from 57

to 368 ppm were detected in the undigested rice grains that confirmed pesticide intoxication

in the pheasant-tailed jacana Identification of suspected poisoning cases relies on

chromatographic determination for carbamate and organophosphates or with cholinesterase

inhibition on a thin layer chromatography plate and enzymatic biochemistry analysis to confirm

the activity of the compound

Mainly carbofuran with few oxamyl deltamethrin carbendazim imidacloprid and prochloraz

were detected in the rice grains of the crops and gizzard contents in the dead birds Carbufuran

is a kind of carbamate insecticide Other carbamate insecticides like carbaryl aldicarb and

methomyl and all have been established uses as agricultural insecticides by preventing

metabolism of acetylcholine at cholinergic synapses of pests they are highly toxic to animals

and humans (Hoogduijn et al 2006 Lassiter et al 2007) Carbofuran is a white crystalline

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

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服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

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64

中華民國比較病理學會

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男 出生日期

民國 年 月 日

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會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

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3

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3

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中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

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審核結果

66

獸醫三館

校園出入口

30

solid with a slightly phenolic odor and products names include Furadanreg Niagarareg 10242

Brifurreg Chinufurreg Curaterrreg Yaltoxreg and 好年冬reg (in Taiwan) Carbofuran usually use to

control insects mites and nematodes in soil and on leaves in a variety of field fruit and

vegetable crops (Zhang et al 2007) The LD50 of rat oral is 8 mgkg and mallard duck oral is

0397 mgkg There are large differences of toxic doses in many species In toxic reaction low

dose of carbofuran significantly decreased brain AChE activity the higher doses produce

relatively greater decrease in motor activity to paralyze respiratory function (McDaniel et al

2007)

From reference reports pesticide poisons in wild birds are commonly caused by

organophosphates (Ops) and carbamates Ops pesticides include monocrotophus fenthion

parathion EPN and diazinon and carbamate carbofuran (Kwon et al 2004) Further

references about pesticide poisoning in wild birds revealed that some birds were submitted

alive with neurologic signs such as convulsions lethargy and paralysis (Berny et al 2008

Wobeser et al 2004) At necropsy no specific gross lesions were observed in most dead birds

Ingested grains were found in the upper digestive tracts of those birds The changes in birds

affected due to carbamate and OP toxicity were mostly biochemical intoxication For this gross

and microscopic examinations of organs could not be observed due to rapid death The above

compounds might not be detectable in the sampled birds due to their rapid breakdown as a

result of shorter half-life Brain AChE activity is used commonly to identify anticholinesterase

poisoning but interpretation is difficult for specimens collected in the field because AChE

activity of chemicals have a variable effect and conditions between death and specimen

analysis are also highly variable Analysis of brain cholinesterase activity is widely used as a

diagnostic technique but using this method always requires knowledge of the normal value for

each species and it may be confounded as well by postmortem decomposition (Wobeser et al

2004) In this case although no background data of brain AChE activity results revealed that

activity of brain AChE was inhibited by 891   21 in dead birds when compared with normal

hens

The treatment of poisonings produced by AChE inhibitors has remained unchanged for many

decades with the muscarinic antagonist atropine being used as a primary antidote and the dose

is 01-02 mgkg IM or SC Concomitant administration of an anticonvulsant drug such as

diazepam 05-2 mgkg IV or IM is considered essential to optimize the regimen of carbamate

pretreatment plus atropine and oxime therapy for severely exposed casualties (Plumb et al

2008 Shih et al 2007)

Finally the cause of bird death in the fields is generally closely associated with methods of

pesticide application The most common route of exposure to pesticides in wild animals is by

ingestion of poisoned insects carcasses or grains intentionally treated with pesticide for bait In

this case for saving money farmers sowed the rice by hand instead of traditionally

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

31

transplanting rice by machines For this they sprayed the rice grains with high concentrations

of pesticide inside to kill or deter wild birds which eat the grains However how to protect wild

animals included pheasant-tailed jacana in the conservation areas for the ecosystemic safety

between wild birds and economy balance needs to concern as well

References 1 翁榮炫王建平水雉的生殖生物學研究第二屆鳥類研討會論文集43-521999

2 Berny P and Gaillet JR Acute poisoning of red kite (Milvus milvus) in France data from the sagir network

Wildl Dis 44 417-426 2008

3 Chen TC Lin YS Ding TS Time Budget of Polyandrous Pheasant-Tailed Jacana (Hydrophasianus chirurgus)

during Breeding Seaon in Taiwan Taiwania 53(2) 107-115 2008

4 Hoogduijn MJ Rakonczay Z Genever PG The effects of anticholinergic insecticides on human mesenchymal

stem cells Toxicol Sci 94 342-350 2006

5 Kwon YK Wee SH and Kim JH Pesticide poisoning events in wild birds in Korea from 1998 to 2002 Wildl Dis

40 737-740 2004

6 Lassiter TL Brimijoin S A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicol Sci 96 154-161 2007

7 McDaniel KL Padilla S Marshall RS Phillips PM Podhorniak L Qian Y Moser VC Comparison of acute

neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat Toxicol Sci 98 552-560

2007

8 Moser VC McDaniel KL Philips PM Lowit AB Time-course dose-response and age comparative sensitivity of

N-methyl carbamates in rats Toxicol Sci 114 113-123 2010

9 Plumb DC Plumbrsquos veterinary drug handbook 6th ed Blackwell Publishing Professional Iowa USA 112-116

369-372 2008

10 Shih TM Rowland TC McDonough JH Anticonvulsants for nerve agent-induced seizures the influence of the

therapeutic dose of atropine J Pharmacol Exp Ther 320 154-161 2007

11 Smulders CJGM Kleef RGDM Groot A Gotti C Vijverberg PM A noncompetitive sequential mechanism for

inhibition of rat α4β2 neuronal nicotinic acetylcholine receptors by carbamate pesticides Toxicol Sci 82

219-227 2004

12 Wobeser G Bollinger T Leighton FA Blakley B Mineau P Secondary poisoning of eagles following intentional

poisoning of coyotes with anticholinesterase pesticides in western Canada Wildl Dis 40 163-172 2004

13 Zhang X Tsang AM Okino MS Power FW Knaak JB Harrison LS Dary CC A physiologically based

pharmacokineticpharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related

dose estimating model Toxicol Sci 100 345-359 2007

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

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40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

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國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

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(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

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蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

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申請人 簽章

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介紹人 簽章

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審核結果

66

獸醫三館

校園出入口

32

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE HISTORY

Signalment 3-4 years-old intact male mixed-breed stray dog

Clinical History This dog was found in the street and was sent to NTUVH at the same day

because there were many cutaneous nodules in the body of dog Upon physical examination

the dog showed anorexia and malnutrition This dog had 6-8 dehydration and poor hair coat

with severe malodor Generalized-distributed cutaneous nodules were observed some of which

were ulcerated especially on both side of trunk oozed out pus-like materials with severe

external parasite infested The nodules were round to oval and estimated 3-5 cm in diameter

On laboratory examination blood examination revealed moderate anemia severe leukocytosis

with left shift and hypoalbuminemia Blood parasite was not noted in microscopic blood smear

examination However Anaplasma platys was found in ELISA test (commercial kit) FNA test

for cutaneous nodules was performed and revealed many round cells with marked cytoplasmic

vacuolization Few mitotic figures were also found

Gross Findings Many nodules located on the trunk head limbs and bilateral conjunctival

mucosa but not on abdominal region The nodules were round to oval in shape and some were

ulcerated or hemorrhagic Oral mucosa showed pale and some area of gum were ulcerated A

fistula from palate to oral cavity was noted When the cutaneous nodules were flayed the

nodules didnrsquot invade to muscular layer and easily separated from epimysium and the cut

surface of nodules were homogeneous light yellowish in color The texture of nodules were firm

and the fringe were well-demarcated from nearby tissue Left lateral medial caudal lobe of the

lung showed redness and wet The hemorrhagic area and swelling were noted in

retropharyngeal lymph node and the left retropharyngeal lymph node was 13 times bigger

than the right one The hepatic lobule were obvious

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

33

Case Number 346 Chinese Society of Comparative Pathology July 2010

Chan TY(詹德裕) DVM Chang PH(張本恆) DVM PhD

School of Veterinary Medicine National Taiwan University (國立臺灣大學獸醫專業學院)

CASE RESULT

Histopathology Description Neoplasm are partially encapsuled and demarcated to the

surroundings and expand from the dermis to the underlying muscular layer The neoplastic

cells are arranged to form sheets and closely-packed with few fibrovascular stroma interlacing

in these cells Neoplastic cells are round to polygonal with obvious cellular borders Vacuoles

containing abundant eosinophilic substance are found in the cytoplasm The nucleus shows

anisokaryosis which locates centrally to cell The nucleolus isnrsquot obvious Mitoses are 1-2 per

HPF Neoplastic cells metastasis of retropharyngeal lymph node is noted Demodex canis are

discovered in hair follicles

Virtual Slide

http140112968382CSCP49CSCPcase3463708svs

User Name guest Password guest

Differential Diagnosis

1 Transmissible venereal tumor

2 Histocytoma

3 Lymphoma

4 Merkel cell tumor

Immunohistochemistry The round cells are immunohistochemically positive for lysozyme

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

34

neuron-specific enolase vimentim and negative for CD3 CD79 CD45 CK Melan A

Myeloperoxidase

Diagnosis Transmissible venereal tumor

Comment Canine cutaneous round cell tumor should be considered several tumors like

transmissible veneral tumor histocytoma lymphoma merkal cell tumor plasmacytoma and

mast cell tumor and every tumor has the feature to diagnose Several methods can help to

differentiate these tumor like fine needle aspiration histopathology immunochemistry staining

and polymerase chain reaction In this case according to the result of fine needle aspiration

and polymerase chain reaction the tumor is diagnosed as transmissible venereal tumor

Transmissible venereal tumor transmitted by viable tumor cells spread from infected dogs or

bitches during coitus or by licking or rubbing The exact incidence of TVT is not known

References 1 Goldschmidt MH Hendrick MJ Tumors of the skin and soft tissues In Meuten DJ Tumors in domestic

animals4th edi Blackwell Publishing 2002

2 Thelma LG Peter JI Emily JW Verena KA Skin dieases of the dog and cat 2nd edi Blackwell

publishing 2006

3 Ginn PE Mansell JEKL Rakich PM Skin and appendages In Maxie MG Pathology of domestic animals

5th edi Elsevier Saunders China 2007

4 Fernandez NJ West JH Jackson ML Kidney BA Immunohistochemical and histochemical Stains for

differentiating Canine cutaneous round cell tumors Vet Pathol 2005 42437ndash445

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

35

中華民國比較病理學會數位式組織切片影像資料庫 How-To Access Chinese Society of Comparative Pathology Virtual Slides

at the Web Library in NTU Vet Med Digital Pathology Lab

Chinese Society of Comparative Pathology slides are now digitalized and accessible to all

participants through the internet and a web browser (see below for detail instruction)

1 Please make sure that your web browser (eg Internet Explorer Firefox or Safari) is equipped

with flash player If not it can be added from httpwwwadobecomproductsflashplayer for

free

2 Please go to the NTU Vet Med Digital Pathology Lab web site at

http140112968382CSCP with your web browser

3 A pop-up window appears to ask for User name and Password Enter ldquoguest for both

boxes

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

36

4 Choose a Comparative Pathology meeting (eg 48CSCP)

5 Pick any case youd like to read (eg case335)

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

37

6 Click on WebVeiwer right lower to the slide thumbnail

7 You now can control the internet microscope to view the slide with your mouse and the

control-icons at the lower center corner of the window The signalment of the case is shown in

the ldquoAnnotationrdquo column on the right

38

8 To maximize your viewing window you may choice to hide the ldquoAnnotationrdquo column by click

on the square box at the right upper corner of the window

9 The highest resolution is at 40X objective at any corner of the slide showing on the

thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

10 Some of us find that our viewing experience on the slides is better with the ImageScope

software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

38

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thumbnail There is a red square in the thumbnail to tell you where you are on the slide

39

9 You may also choice to read the slides with a free ImageScope software by clicking on

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40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

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9 You may also choice to read the slides with a free ImageScope software by clicking on

ImageScope left lower to the slide thumbnail Follow the instruction appears in a pop-up

window to download and install the software if you have not done so

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software than with a web browser

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

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中華民國比較病理學會秘書處

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國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

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中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

40

中華民國比較病理學會

第一次至第四十九次比較病理學研討會病例分類一覽表

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 1 Myxoma Dog 美國紐約動物醫學中

2 Chordoma Ferret 美國紐約動物醫學中

3 Ependymoblastoma Human 長庚紀念醫院

8 Synovial sarcoma Pigeon 美國紐約動物醫學中

18 Malignant lymphoma Human 長庚紀念醫院

19 Malignant lymphoma Wistar rat 國家實驗動物繁殖及

研究中心

24 Metastatic thyroid carcinoma Human 省立新竹醫院

25 Chordoma Human 新光吳火獅紀念醫院

34 Interstitial cell tumor Dog 中興大學獸醫學系

35 Carcinoid tumor Human 長庚紀念醫院

36 Hepatic carcinoid Siamese cat 美國紐約動物醫學中

38 Pheochromocytoma Ferret 美國紐約動物醫學中

39 Extra adrenal pheochromocytoma Human 新光吳火獅紀念醫院

40 Mammary gland fibroadenoma Rat 國家實驗動物繁殖及

研究中心

41 Fibroadenoma Human 省立豐原醫院

42 Canine benign mixed type mammary

gland tumor

Pointer bitch 中興大學獸醫學系

43 Phyllodes tumor Human 台中榮民總醫院

44 Canine oral papilloma Dog 國立臺灣大學獸醫專

業學院

45 Squamous cell papilloma Human 中國醫藥學院

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland right carcinoma

(primary)

Human 三軍總醫院

56 Gastrointestinal stromal tumor Human 台中榮民總醫院

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

41

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 59 Colonic adenocarcinoma Dog 美國紐約動物醫學中

62 Submucosal leiomyoma of stomach Human 頭份為恭紀念醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

71 Myelolipoma Human 天主教耕莘醫院

72 Reticulum cell sarcoma Mouse 國家實驗動物繁殖及

研究中心

73 Hepatocellular carcinoma Human 新光吳火獅紀念醫院

74 Hepatocellular carcinoma induced by

aflatoxin B1

Wistar strain

rats

台灣省農業藥物毒物

試驗所

81 Angiomyolipoma Human 羅東博愛醫院病理科

82 Inverted papilloma of prostatic urethra Human 省立新竹醫院

84 Nephrogenic adenoma Human 國泰醫院

86 Multiple myeloma with systemic

amyloidosis

Human 佛教慈濟綜合醫院

87 Squamous cell carcinoma of renal pelvis

and calyces with extension to the ureter

Human 台北病理中心

88 Fibroepithelial polyp of the ureter Human 天主教耕莘醫院

90 Clear cell sarcoma of kidney Human 台北醫學院

93 Mammary gland adenocarcinoma

complex type with chondromucinous

differentiation

Dog 國立臺灣大學獸醫專業

94 1Breast left modified radical

mastectomy showing papillary

carcinoma invasive

2Nipple left modified radical

mastectomy papillary carcinoma

invasive

3Lymph node axillary left

lymphadenectomy palillary carcinoma

metaststic

Human 羅東聖母醫院

95 Transmissible venereal tumor Dog 中興大學獸醫學系

96 Malignant lymphoma large cell type

diffuse B-cell phenotype

Human 彰化基督教醫院

97 Carcinosarcomas Tiger 台灣養猪科學研究所

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

42

分 類 病例

編號 診 斷 動物別 提 供 單

腫 瘤 98 Mucinous carcinoma with intraductal

carcinoma

Human 省立豐原醫院

99 Mammary gland adenocarcinoma type

B with pulmonary metastasis

BALBcBYJ mouse

Mouse 國家實驗動物繁殖及研

中心

100 Malignant fibrous histiocytoma and

paraffinoma

Human 中國醫藥學院

102 Pleomorphic adenoma (benign mixed

tumor)

Human 佛教慈濟綜合醫院

103 Atypical central neurocytoma Human 新光吳火獅紀念醫院

104 Cardiac schwannoma SD rat 國家實驗動物繁殖及

研究中心

109 Desmoplastic infantile ganglioglioma Human 高雄醫學院

107 1Primary cerebral malignant

lymphoma

2Acquired immune deficiency

syndrome

Human 台北市立仁愛醫院

111 Schwannoma Human 三軍總醫院

114 Osteosarcoma Dog 美國紐約動物醫學中

115 Mixed germ-cell stromal tumor mixed

sertoli cell and seminoma-like cell

tumor

Dog 美國紐約動物醫學中

116 Krukenbergrsquos Tumor Human 台北病理中心

117 Primary insular carcinoid tumor arising

from cystic teratoma of ovary

Human 佛教慈濟綜合醫院

119 Polypoid adenomyoma Human 大甲李綜合醫院

120 Gonadal stromal tumor Human 天主教耕莘醫院

122 Gestational choriocarcinoma Human 彰化基督教醫院

123 Ovarian granulosa cell tumor Horse 中興大學獸醫學系

129 Kaposis sarcoma Human 華濟醫院

131 Basal cell carcinoma (BCC) Human 羅東聖母醫院

132 Transmissible venereal tumor Dog 國立臺灣大學獸醫專

業學院

137 Canine Glioblastoma Multiforme in

Cerebellopontine Angle

Dog 中興大學獸醫病理研

究所

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

43

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 143 Osteosarcoma associated with metallic

implants

Dog 紐約動物醫學中心

144 Radiation-induced osteogenic sarcoma Human 佛教慈濟綜合醫院

145 Osteosarcoma osteogenic Dog 國立臺灣大學獸醫專

業學院

146 Pleomorphic rhabdomyosarcoma Human 行政院衛生署新竹醫

147 Papillary Mesothelioma of pericardium Leopard 屏東科大學獸醫學系

148 Cystic ameloblastoma Human 台北醫學院

149 Giant cell tumor of bone Canine 中興大學獸醫學院

150 Desmoplastic small round cell tumor

(DSRCT)

Human 華濟醫院

152 Hepatocellular carcinoma Human 羅東聖母醫院

158 Hemangiopericytoma Human 羅東聖母醫院

160 Cardiac fibroma Human 高雄醫學大學病理學

166 Nephroblastoma Rabbit 紐約動物醫學中心

168 Nephroblastoma Pig 台灣動物科技研究所

169 Nephroblastoma with rhabdomyoblastic

differentiation

Human 高雄醫學大學病理科

172 Spindle cell sarcoma Human 羅東聖母醫院

174 Juxtaglomerular cell tumor Human 新光醫院病理檢驗科

190 Angiosarcoma Human 高雄醫學大學病理學

192 Cardiac myxoma Human 彰化基督教醫院病理

194 Kasabach-Merrit syndrome Human 佛教慈濟綜合醫院

195 Metastatic hepatocellular carcinoma

right atrium

Human 新光醫院病理科

197 Papillary fibroelastoma of aortic valve Human 新光醫院病理科

198 Extraplacental chorioangioma Human 天主教耕莘醫院

208 Granulocytic sarcoma (Chloroma) of

uterine cervix

Human 高雄醫學大學病理學

210 Primary non-Hodgkins lymphoma of

bone diffuse large B cell right humerus

Lymphoma 彰化基督教醫院病理

213 Lymphoma multi-centric type Dog 中興大學獸醫系

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

44

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 214 CD30 (Ki-1)-postitive anaplastic large

cell lymphoma (ALCL)

Human 新光醫院病理科

215 Lymphoma mixed type Koala 國立臺灣大學獸醫專

業學院

217 Mucosal associated lymphoid tissue

(MALT) lymphoma small intestine

Cat 國立臺灣大學獸醫專

業學院

218 Nasal type NKT cell lymphoma Human 高雄醫學大學病理科

222 Acquired immunodeficiency syndrome

(AIDS)with disseminated Kaposis

sarcoma

Human 佛教慈濟綜合醫院

224 Epithelioid sarcoma Human 彰化基督教醫院病理

226 Cutaneous B cell lymphoma eyelid

bilateral

Human 羅東聖母醫院病理科

227 Extramammary Pagets disease

(EMPD)

of the scrotum

Human 萬芳北醫皮膚科病理

228 Skin back excision CD30+diffuse

large B cell lymphoma Soft tissue leg

side not stated excision vascular

leiomyoma

Human 高雄醫學大學附設醫

院病理科

231 Malignant melanoma metastasis to

intra-abdominal cavity

Human 天主教耕莘醫院

232 Vaccine-associated rhabdomyosarcoma Cat 國立臺灣大學獸醫專

業學院

233 1 Pleura fibrous plaque 2 Lung

adenocarcinoma 3 Brain metastatic

adenocarcinoma

Human 高雄醫學大學附設中

和醫院病理科

235 1 Neurofibromatosis type I

2 Malignant peripheral nerve sheath

tumor (MPNST)

Human 佛教慈濟綜合醫院

239 Glioblastoma multiforme Human 羅東聖母醫院

240 Pineoblastoma Wistar rat 綠色四季

241 Chordoid meningioma Human 高醫病理科

243 Infiltrating lobular carcinoma of left

breast with meningeal carcinomatosis

and brain metastasis

Human 佛教慈濟綜合醫院

245 Microcystic Meningioma Human 天主教耕莘醫院

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

45

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 247 Well-differentiated fetal

adenocarcinoma without lymph node

metastasis

Human 新光吳火獅紀念醫院

249 Adenocarcinoma of lung Human 羅東聖母醫院

252 Renal cell carcinoma Canine 國立臺灣大學獸醫專

業學院

253 Clear cell variant of squamous cell

carcinoma lung

Human 高雄醫學大學附設中

和醫院病理科

256 Metastatic adrenal cortical carcinoma Human 天主教耕莘醫院

258 Hashimotos thyroiditis with diffuse

large B cell lymphoma and papillary

carcinoma

Human 高雄醫學大學附設中

和醫院病理科

262 Medullar thyroid carcinoma Canine 國立臺灣大學獸醫專

業學院

264 Merkel cell carcinoma Human 羅東博愛醫院

266 Cholangiocarcinoma Human 天主教耕莘醫院

268 Sarcomatoid carcinoma of renal pelvis Human 佛教慈濟綜合醫院

269 Mammary Carcinoma Canine 中興大學獸醫學系

270 Metastatic prostatic adenocarcinoma Human 天主教耕莘醫院

271 Malignant canine peripheral nerve

sheath tumors

Canine 國立臺灣大學獸醫專

業學院

272 Sarcomatoid carcinoma lung Human 羅東聖母醫院

273 VertebraT12laminectomy metastatic

adenoid cystic carcinoma

Human 彰化基督教醫院

274 rhabdomyosarcoma Canine 國立臺灣大學獸醫專

業學院

275 Fetal rhabdomyosarcoma SD Rat 中興大學獸醫學系

276 Adenocarcinoma metastatic iris eye Human 高雄醫學大學

277 Axillary lymph node metastasis from an

occult breast cancer

Human 羅東博愛醫院病理科

278 Hepatocellular carcinoma Human 國軍桃園總醫院

279 Feline diffuse iris melanoma Faline 中興大學獸醫學系

280 Metastatic malignant melanoma in the

brain and inguinal lymph node

Human 佛教慈濟綜合醫院

281 Tonsil Angiosarcoma Human 羅東博愛醫院病理科

282 Malignant mixed mullerian tumor Human 天主教耕莘醫院

283 Renal cell tumor Rat 中興大學獸醫學系

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

46

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 284 Multiple Myeloma Human 佛教慈濟綜合醫院

285 Myopericytoma Human 新光吳火獅紀念醫院

287 Extramedullary plasmacytoma with

amyloidosis

Canine 國立臺灣大學獸醫專

業學院

288 Metastatic follicular carcinoma Human 羅東聖母醫院病理科

289 Primitive neuroectodermal tumor

(PNET) T-spine

Human 羅東博愛醫院病理科

292 Hemangioendothelioma of bone Human 佛教慈濟綜合醫院

293 Malignant tumor with perivascular

epithelioid differentiation favored

malignant PEComa

Human 彰化基督教醫院

297 Mucin-producing cholangiocarcinoma Human 基隆長庚醫院

300 Cutaneous epitheliotropic lymphoma Canine 國立臺灣大學獸醫專

業學院

301 Cholangiocarcinoma Felis Lynx 國立臺灣大學獸醫專

業學院

302 Lymphoma Canine 國立臺灣大學獸醫專

業學院

303 Solitary fibrous tumor Human 彰化基督教醫院

304 Multiple sarcoma Canine 國立臺灣大學獸醫專

業學院

306 Malignant solitary firous tumor of

pleura

Human 佛教慈濟綜合醫院

307 Carcinoma with thymus-like element Human 彰濱秀傳紀念醫院

308 Medullary carcinoma of right lobe of

thyroid

Human 彰化基督教醫院

309 Thyroid carcinosarcoma with cartilage

and osteoid formation

Canine 國立臺灣大學獸醫專

業學院

312 Systemic T- lymphocytic

leukemialymphoma

Koala 國立臺灣大學獸醫專

業學院

313 Neuroendocrine carcinoma of liver Human 佛教慈濟綜合醫院

314 Parachordoma Human 羅東博愛醫院病理科

315 Carcinoma ex pleomorphic adenoma

submandibular gland

Human 天主教耕莘醫院

316 Melanoma tongue Canine 國立臺灣大學獸醫專

業學院

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

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中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

47

分 類 病例

編號 診 斷 動物別 提 供 單 位

腫 瘤 317 Renal cell carcinoma papillary type Canine 國立臺灣大學獸醫專

業學院

323 Metastatic papillary serous

cystadenocarcinoma abdomen

Human 國軍桃園總醫院

324 Malignant gastrointestinal stromal tumor Human 天主教耕莘醫院

329 Sclerosing stromal tumor Human 彰化基督教醫院

330 Pheochromocytoma Human 天主教耕莘醫院

334 Metastatic infiltrating ductal carcinoma

liver

Human 佛教慈濟綜合醫院

335 Adenoid cystic carcinoma grade II Rt

breast

Human 天主教耕莘醫院

336 Malignant lymphoma diffuse large

B-cell right neck

Human 林新醫院

337 Pulmonary carcinoma multicentric

Dog 國立臺灣大學獸醫專

業學院

338 Malignant melanoma multiple organs

metastasis

Rabbit 國立中興大學獸醫學

340 Mucinous-producing urothelial-type

adenocarcinoma of prostate Human 天主教耕莘醫院

342 Plexiform fibromyxoma Human 彰化基督教醫院

343 Malignant epithelioid trophoblastic tumor Human 佛教慈濟綜合醫院

344 Epithelioid sarcoma Human 林新醫院

346 Transmissible venereal tumor Dog

國立臺灣大學獸醫

專業學院

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

48

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 6 Tuberculosis Monkey 國立臺灣大學獸醫專

業學院

7 Tuberculosis Human 省立新竹醫院

12 H pylori-induced gastritis Human 台北病理中心

13 Pseudomembranous colitis Human 省立新竹醫院

26 Swine salmonellosis Pig 中興大學獸醫學系

27 Vegetative valvular endocarditis Pig 台灣養猪科學研究所

28 Nocardiosis Human 台灣省立新竹醫院

29 Nocardiosis Largemouth

bass

屏東縣家畜疾病防治

32 Actinomycosis Human 台灣省立豐原醫院

33 Tuberculosis Human 苗栗頭份為恭紀念醫

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

58 Tuberculous enteritis with perforation Human 佛教慈濟綜合醫院

61 Spirochetosis Goose 國立嘉義農專獸醫科

63 Proliferative enteritis (Lawsonia intracellularis infection)

Porcine 屏東縣家畜疾病防治

68 Liver abscess (Klebsillae pneumoniae) Human 台北醫學院

77 1 Xanthogranulomatous inflammation

with nephrolithiasis kidney right

2 Ureteral stone right

Human 羅東聖母醫院

79 Emphysematous pyelonephritis Human 彰化基督教醫院

89 1 Severe visceral gout due to kidney

damaged

2 Infectious serositis

Goose 中興大學獸醫學系

108 Listeric encephalitis Lamb 屏東縣家畜疾病防治

113 Tuberculous meningitis Human 羅東聖母醫院

134 Swine salmonellosis with meningitis Swine 中興大學獸醫學系

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

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Tel (02) 33663858

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------------------------------中華民國比較病理學會----------------------------

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65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

49

分 類 病例

編號 診 斷 動物別 提 供 單 位

細菌 135 Meningoencephalitis fibrinopurulent

and lymphocytic diffuse subacute

moderate cerebrum cerebellum and

brain stem caused by Streptococcus

spp infection

Swine 國家實驗動物繁殖及

研究中心

140 Coliform septicemia of newborn calf Calf 屏東縣家畜疾病防治

161 Porcine polyserositis and arthritis

(Glassers disease)

Pig 中興大學獸醫學院

162 Mycotic aneurysm of jejunal artery

secondary to infective endocarditis

Human 佛教慈濟綜合醫院

170 Chronic nephritis caused by Leptospira

spp

Pig 中興大學獸醫學院

173 Ureteropyelitis and cystitis Pig 中國化學製藥公司

254 Pulmonary actinomycosis Human 天主教耕莘醫院

259 Tuberculous peritonitis Human 彰化基督教醫院病理

260 Septicemic salmonellosis Piglet 屏東科技大學獸醫系

261 Leptospirosis Human 佛教慈濟綜合醫院

267 Mycobacteriosis Soft turtles 屏東科技大學獸醫系

290 Staphylococcus spp infection Formosa

Macaque

中興大學獸醫病理學

研究所

291 Leptospirosis Dog 國立臺灣大學獸醫專

業學院

296 Leptospirosis Human 佛教慈濟綜合醫院

305 Cryptococcus and Tuberculosis Human 彰濱秀傳紀念醫院

319 Placentitis Coxiella burnetii Goat 台灣動物科技研究所

321 Pneumonia Buirkholderia pseudomallei Goat 屏東縣家畜疾病防治

339 Mycoplasmosis Rat 國家實驗動物中心

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

50

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 21 Newcastle disease Chickens 國立臺灣大學獸醫專

業學院

22 Herpesvirus infection Goldfish 國立臺灣大學獸醫專

業學院

30 Demyelinating canine distemper

encephalitis

Dog 台灣養猪科學研究所

31 Adenovirus infection Malayan sun

bears

國立臺灣大學獸醫專

業學院

50 Porcine cytomegalovirus infection Piglet 台灣省家畜衛生試驗

55 Infectious laryngo-tracheitis

(Herpesvirus infection)

Broilers 國立屏東技術學院獸

醫學系

69 Pseudorabies (Herpesvirus infection) Pig 台灣養猪科學研究所

78 Mareks disease in native chicken Chicken 屏東縣家畜疾病防治

92 Foot- and- mouth disease (FMD) Pig 屏東縣家畜疾病防治

101 Swine pox Pig 屏東科技大學獸醫學

110 Pseduorabies Piglet 國立屏東科技大學

112 Avian encephalomyelitis Chicken 國立中興大學

128 Contagious pustular dermatitis Goat 屏東縣amp台東縣家畜

疾病防治所

130 Fowl pox and Mareks disease Chicken 中興大學獸醫學系

133 Japanese encephalitis Human 佛教慈濟綜合醫院

136 Viral encephalitis polymavirus infection Lory 美國紐約動物醫學中

138 1Aspergillus spp encephalitis and

myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

153 Enterovirus 71 infection Human 彰化基督教醫院

154 Ebola virus infection African Green

monkey

行政院國家科學委員

會實驗動物中心

155 Rabies Longhorn

Steer

國立臺灣大學獸醫專

業學院

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

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年 月 年 月

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中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

51

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 163 Parvoviral myocarditis Goose 屏東科技大學獸醫學

199 SARS Human 台大醫院病理科

200 TGE virus swine 臺灣動物科技研究所

201 Feline infectious peritonitis(FIP) Feline 國立臺灣大學獸醫專

業學院

209 Chicken Infectious Anemia (CIA) Layer 屏東防治所

219 1Lymph nodeLymphdenitis with

lymphocytic depletion and

intrahistiocytic basophilic cytoplasmic

inclusion bodies Etiology consistent

with Porcine Circovirus(PCV)infection

2Lung Bronchointerstitial

pneumoniamoderate

lymphoplasmacytic subacute

Pig 臺灣動物科技研究所

220 Cytomegalovirus colitis Human 彰化基督教醫院病理

221 Canine distemper virus

Canine adenovirus type ll co-infection

Canine 國家實驗動物繁殖及

研究中心

223 1 Skin mucocutaneous junction (lip)

Cheilitis with epidermal pustules

ballooning degeneration proliferation

and eosinophilic intracytoplasmic

inclusion bodies Saanen goat

2 Haired skin Dermatitis proliferative

lymphoplasmacytic with marked

epidermal pustules ballooning

degeneration acanthosis

hyperkeratosis and eosinophilic

intracytoplasmic inclusion bodies

Goat 台灣動物科技研究所

238 Hydranencephaly Cattle 國立屏東科技大學獸

醫學系

248 Porcine Cytomegalovirus (PCMV)

infection

Swine 國立屏東科技大學獸

醫學系

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

52

分 類 病例

編號 診 斷 動物別 提 供 單 位

病毒 250 Porcine respiratory disease complex

(PRDC) and polyserositis caused by

co-infection with pseudorabies (PR)

virus porcine circovirus type 2 (PCV 2)

porcine reproductive and respiratory

syndrome (PRRS) virus and Salmonella typhimurium

Swine 屏東縣家畜疾病防所

255 Vaccine-induced canine distemper gray foxes 國立臺灣大學獸醫專

業學院

265 Bronchointerstitial pneumonia

(PCV II infection)

Swine 國立臺灣大學獸醫專

業學院

295 Feline infectious peritonitis (FIP) Cat 中興大學獸醫病理所

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

53

分 類 病例

編號 診 斷 動物別 提 供 單 位

黴菌 23 Chromomycosis Human 台北病理中心

47 Lung metastatic carcinoma associated

with cryptococcal infection

Liver metastatic carcinoma

Adrenal gland carcinoma (primary)

Human 三軍總醫院

48 Adiaspiromycosis Wild rodents 國立臺灣大學獸醫專

業學院

52 Aspergillosis Goslings 屏東縣家畜疾病防治

53 Intracavitary aspergilloma and cavitary

tuberculosis lung

Human 羅東聖母醫院

54 Fibrocalcified pulmonary TB left Apex

Mixed actinomycosis and aspergillosis

lung infection with abscess DM

NIDDM

Human 林口長庚紀念醫院

105 Mucormycosis

Diabetes mellitus

Human 佛教慈濟綜合醫院

127 Eumycotic mycetoma Human 佛教慈濟綜合醫院

138 1Aspergillus spp encephalitis and myocarditis

2Demyelinating canine distemper

encephalitis

Dog 國立臺灣大學獸醫專

業學院

298 Systemic Candidiasis Tortoise 中興大學獸醫學院

322 Allergic fungal sinusitis Human 羅東博愛醫院

326 Meningoencephalitis Aspergillus flavus Cat 國立臺灣大學獸醫專

業學院

331 Histoplasmosis Human 花蓮慈濟醫院病理科

332 Pulmonary Blastomycosis Rat 中興大學獸醫學院

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

54

分 類 病例

編號 診 斷 動物別 提 供 單 位

寄生

14 Dirofilariasis Dog 台灣省家畜衛生試驗

15 Pulmonary dirofilariasis Human 台北榮民總醫院

20 Sparganosis Human 台北榮民總醫院

46 Feline dirofilariasis Cat 美國紐約動物醫學中

49 Echinococcosis Human 台北榮民總醫院

60 Intestinal capillariasis Human 台北馬偕醫院

64 1Adenocarcinoma of sigmoid colon

2Old schistosomiasis of rectum

Human 省立新竹醫院

66 Echinococcosis Chapmans

zebra

國立臺灣大學獸醫專

業學院

67 Hepatic ascariasis and cholelithiasis Human 彰化基督教醫院

106 Parasitic meningoencephalitis caused

by Toxocara canis larvae migration

Dog 臺灣養猪科學研究所

139 Disseminated strongyloidiasis Human 佛教慈濟綜合醫院

141 Eosinophilic meningitis caused by

Angiostrongylus cantonensis

Human 台北榮民總醫院病理

檢驗部

156 Parastrongylus cantonensis infection Formosan

gem-faced

civet

中興大學獸醫學院

157 Capillaria hepatica

Angiostongylus cantonensis

Norway Rat 行政院農業委員會農

業藥物毒物試驗所

202 Colnorchiasis Human 高雄醫學院附設醫院

203 Trichuriasis Human 彰化基督教醫院

204 Psoroptes cuniculi infection (Ear mite) Rabbit 農業藥物毒物試驗所

205 Pulmonary dirofilariasis Human 和信治癌中心醫院

206 Capillaries philippinesis Human 和信治癌中心醫院

207 Adenocarcinoma with schistosomiasis Human 佛教慈濟綜合醫院

286 Etiology- consistent with Spironucleus (Hexamita) muris

Rat 國家實驗動物中心

327 Dermatitis mange infestation Serow 中興大學獸醫學院

328 Trichosomoides crassicauda urinary bladder

Rat 國家實驗動物中心

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

55

分 類 病例

編號 診 斷 動物別 提 供 單 位

原蟲 4 Cryptosporidiosis Goat 台灣養猪科學研究所

15 Amoebiasis Lemur fulvus 台灣養猪科學研究所

16 Toxoplasmosis Squirrel 台灣養猪科學研究所

17 Toxoplasmosis Pig 屏東技術學院獸醫學

51 Pneumocystis carinii pneumonia Human 台北病理中心

57 Cecal coccidiosis Chicken 中興大學獸醫學系

65 Cryptosporidiosis Carprine 台灣養猪科學研究所

211 Avian malaria African black-footed

penguin

Avian 臺灣動物科技研究所

242 Neosporosis Cow 國立屏東科技大學獸

醫學系

263 Intestinal amebiasis Human 彰化基督教醫院病理

320 Cutaneous leishmaniasis Human 佛教慈濟綜合醫院

325 Myocarditisencephalitis Toxoplasma gondii

Wallaby 國立臺灣大學獸醫專

業學院

分 類 病例

編號 診 斷 動物別 提 供 單 位

立克

次體

229 Necrotizing inflammation due to scrub

typhus

Human 佛教慈濟綜合醫院

251 Scrub typhus with diffuse alveolar

damage in bilateral lungs

Human 佛教慈濟綜合醫院

分 類 病例

編號 診 斷 動物別 提 供 單 位

皮膚 216 Cytophagic histiocytic panniculitis with

terminal hemophagocytic syndrome

Human 佛教慈濟綜合醫院

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

56

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 9 Perinephric pseudocyst Cat 國立臺灣大學獸醫專

業學院

10 Choledochocyst Human 長庚紀念醫院

11 Bile duct ligation Rat 中興大學獸醫學系

37 Myositis ossificans Human 台北醫學院

75 Acute yellow phosphorus intoxication Rabbits 中興大學獸醫學系

76 Polycystic kidney bilateral and renal

failure

Cat 美國紐約動物醫學中

151 Osteodystrophia fibrosa Goat 台灣養猪科學研究所

amp台東縣家畜疾病防

治所

80 1Glomerular sclerosis and hyalinosis

segmental focal chronic moderate

2Benign hypertension

SHR rat 國防醫學院 amp 國家

實驗動物繁殖及研究

中心

83 Phagolysosome-overload nephropathy SD rats 實驗動物繁殖及研究

中心

85 Renal amyloidosis Dog 台灣養猪科學研究所

89 1Severe visceral gout due to kidney

damaged

2Infectious serositis

Goose 中興大學獸醫學系

91 Hypervitaminosis D Orange-rumpe

d agoutis

國立臺灣大學獸醫專

業學院

118 Cystic endometrical hyperplasia Dog 臺灣養猪科學研究所

121 Cystic subsurface epithelial structure

(SES)

Dog 國科會實驗動物中心

124 Superficial necrolytic dermatitis Dog 美國紐約動物醫學中

125 Solitary congenital self-healing

histiocytosis

Human 羅東博愛醫院病理科

126 Alopecia areata Mouse 實驗動物繁殖及研究

中心

142 Avian encephalomalacia (Vitamin E

deficiency)

Chicken 國立屏東科技大學獸

醫學系

159 Hypertrophic cardiomyopathy Pig 國立臺灣大學獸醫專

業學院

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

57

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 165 Chinese herb nephropathy Human 三軍總醫院病理部及

腎臟科

167 Acute pancreatitis with rhabdomyolysis Human 佛教慈濟綜合醫院

171 Malakoplakia Human 彰化基督教醫院

183 Dariers disease Human 高雄醫學大學病理科

191 1 Polyarteritis nodosa

2 Hypertrophic Cardiomyopathy

Feline 國立臺灣大學獸醫專

業學院

193 Norepinephrin cardiotoxicity Cat 台中榮總

196 Cardiomyopathy (Experimental) Mice 綠色四季

212 Kikuchi disease (histiocytic necrotizing

lymphandenitis)

Lymphandeniti

s

天主教耕莘醫院

225 Calcinosis circumscripta soft tissue of

the right thigh dog

Dog 國立臺灣大學獸醫專

業學院

230 Hemochromatosis liver bird Bird 國立臺灣大學獸醫專

業學院

234 Congenital hyperplastic goiter Holstein calves 屏東縣家畜疾病防治

236 Hepatic lipidosis (fatty liver) Rats 中興大學獸醫學病理

學研究所

237 Arteriovenous malformation (AVM) of

cerebrum

Human 天主教耕莘醫院

244 Organophosphate induced delayed

neurotoxicity

Hens 中興大學獸醫學病理

學研究所

257 Severe lung fibrosis after chemotherapy

in a child with Ataxia- Telangiectasia

Human 佛教慈濟綜合醫院

294 Arteriovenous malformation of the left

hindlimb

Dog 國立臺灣大學獸醫專

業學院

299 Polioencephalomalacia Caprine 屏東家畜疾病防治所

310 Thyroid Follicular Hyperplasia

(hyperplastic goiter)

Porcine 屏東縣家畜疾病防治

311 Melamine and cyanuric acid

contaminated pet food induced

nephrotoxicity

Rat 國立中興大學獸醫學

318 Alfatoxicosis Canine 國立臺灣大學獸醫專

業學院

333 Lordosis C6 to C11 Penguin 國立臺灣大學獸醫專

業學院

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

58

分 類 病例

編號 診 斷 動物別 提 供 單 位

其它 341 Pulmonary placental transmogrification Human 羅東博愛醫院

345 Acute carbofuran intoxication Jacana 國立中興大學獸醫學

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

59

中華民國比較病理學會章程

第一章 總則

第一條 本會定名為中華民國比較病理學會英文名稱為 Chinese Society of

Comparative Pathology (CSCP) (以下簡稱本會)

第二條 本會依內政部人民團體法設立為非營利目的之社會團體以結合人類醫學與

動物醫學資源提倡比較病理學之研究與發展交換研究教學心得聯絡會員

友誼及促進國際間比較醫學之交流為宗旨

第三條 本會以全國行政區域為組織區域會址設於主管機關所在地區並得報經主管

機關核准設主分支機構前項分支機構組織簡則由理事會擬訂報請主管機關

核准後行之會址及分支機構之地址於設置及變更時應報請主管機關核備

第四條 本會之任務如左

一 提倡比較病理學之研究與發展

二 舉辦學術演講會研討會及相關訓練課程

三 建立國內比較醫學相關資料庫

四 發行比較病理學相關刊物

五 促進國內外比較醫學之交流

六 其他有關比較病埋學術發展之事項

第五條 本會之主管機關為內政部目的事業主管機關依章程所訂之宗旨與任務主要

為行政院衛生署及農業委員會其目的事業應受各該事業主管機關之指導與監

第二章 會員

第六條 本會會員申請資格如下

一 一般會員贊同本會宗旨年滿二十歲具有國內外大專院校( 或

同等學歷)生命科學及其它相關科系畢業資格或高職畢業從

事生命科學相關工作滿兩年者

二 學生會員贊同本會宗旨在國內外大專院校生命科學或其它

相關科系肄業者 (檢附學生身份證明)

三 贊助會員贊助本會工作之團體或個人

四 榮譽會員凡對比較病理學術或會務之推展有特殊貢獻經理事

會提名並經會員大會通過者

前項一二三項會員申請時應填具入會申請書經一般會員二人之推薦經

理事會通過並繳納會費學生會員身份改變成一般會員時得再補繳一般會

員入會費之差額後即成為一般會員榮譽會員免繳入會費與常年會費

第七條 一般會員有表決權選舉權被選舉與罷免權每一會員為一權贊助會員

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

60

學生會員與榮譽會員無前項權利

第八條 會員有遵守本會章程決議及繳納會費之義務

第九條 會員有違反法令章程或不遵守會員大會決議時得經理事會決議予以警告

或停權處分其危害團體情節重大者得經會員大會決議予以除名

第十條 會員喪失會員資格或經會員大會決議除名者即為出會

第十一條 會員得以書面敘明理由向本會聲明退會但入會費與當年所應繳納的常年會費

不得申請退費

第三章 組織及職員

第十二條 本會以會員大會為最高權力機構

第十三條 會員大會之職權如下

一 訂定與變更章程

二 選舉及罷免理事監事

三 議決入會費常年會費事業費及會員捐款之方式

四 議決年度工作計畫報告預算及決算

五 議決會員之除名處置

六 議決財產之處分

七 議決本會之解散

八 議決與會員權利義務有關之其他重大事項

前項第八款重大事項之範圍由理事會訂定之

第十四條 本會置理事十五人監事五人由會員選舉之分別成立理事會監事會

選舉前項理事監事時依計票情形得同時選出候補理事五人候補監

事一人遇理事或監事出缺時分別依序遞補之

本屆理事會得提出下屆理事及監事候選人參考名單

第十五條 理事會之職權如下

一 審定會員之資格

二 選舉及罷免常務理事及理事長

三 議決理事常務理事及理事長之辭職

四 聘免工作人員

五 擬訂年度工作計畫報告預算及決算

六 其他應執行事項

第十六條 理監事置常務理事五人由理事互選之並由理事就常務理

事中選舉一人為理事長

理事長對內綜理監督會議對外代表本會並擔任會員大會

理事會主席

理事長因事不能執行職務時應指定常務理事一人代理之

未指定或不能指定時由常務理事互推一人代理之

理事長或常務理事出缺時應於一個月內補選之

第十七條 監事會之職權如左

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

61

一監察理事會工作之執行

二審核年度決算

三選舉及罷免常務監事

四議決監事及常務監事之辭職

五其他應監察事項

第十八條 監事會置常務監事一人由監事互選之監察日常會務並

擔任監事會主席

常務監事因事不能執行職務時應指定監事一人代理之未

指定或不能指定時由監事互推一人代理之監事會主席(常

務監事)出缺時應於一個月內補選之

第十九條 理事監事均為無給職任期三年連選得連任理事長之

連任以一次為限

第二十條 理事監事有下列情事之一者應即解任

一喪失會員資格

二因故辭職經理事會或監事會決議通過者

三被罷免或撤免者

四受停權處分期間逾任期二分之一者

第二十一條 本會置祕書長一人承理事長之命處理本會事務令置其他

工作人員若干人由理事長提名經理事會通過後聘免之並

報主管機關備查但祕書長之解聘應先報主管機關核備

前項工作人員不得由選任之職員(理監事)擔任

工作人員權責及分層負責事項由理事會令另定之

第二十二條 本會得設各種委員會小組或其它內部作業組織其組織簡

則由理事會擬定報經主機關核備後施行變更時亦同

第二十三條 本會得由理事會聘請無給顧問若干人其聘期與理事監事

之任期同

第四章 會議

第二十四條 會員大會分定期會議與臨時會議兩種由理事長召集召集時

除緊急事故之臨時會議外應於十五日前以書面通知之定期會

議每年召開一次臨時會議於理事會過半數認為必要或經會

員五分之一以上之請或監事會半數函請召集時召開之

第二十五條 會員不能親自出席會員大會時得以書面委託其他會員代理

每一會員以代理一人為限

第二十六條 會員大會之決議以出席人數過半之同意行之但章程之訂定與變更會員之

除名理事及監事之罷免財產之處置本會之解散及其他與會權利義務有關

之重大事項應有出席人數三分之二以上同意但本會如果辦理法人登記後章

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

62

程之變更應以出席人數四分之三以上之同或全體會員三分之二以上書面之同意

行之

第二十七條 理事會及監事會至少每六個月各舉行會議一次必要時得召開聯席會議或臨時

會議

前項會議召集時除臨時會議外應於七日以以書面通知會議之決議各以理事監事過

半數之出席出席人較多數之同意行之

第二十八條 理事應出席理事會議監事應出席監事會議不得委託出席理

事監事連續二次無故缺席理事會監事會者視同辭職

第五章 經費及會計

第二十九條 本會經費來源如下

一入會費一般會員新台幣壹仟元學生會員壹佰元贊助會員伍仟元於

入會時繳納

二常年會費一般會員新台幣五佰元學生會員壹佰元

三事業費

四會員捐款

五委託收益

六基金及其孳息

七其他收入

第三十條 本會會計年度以國曆年為準自每年一月一日起至十二月三十

一日止

第三十一條 本會每年於會計年度開始前二個月由理事會編造年度工作計劃收支預算表

員工待遇表提會員大會通過(會員大會因故未能如期召開者先提理監事聯

席會議通過)於會計年度開始前報主管機關核備並於會計年度終了後二個月

內由理事會編造年度工作報告收支決算表現金出納表資產負債表財產

目錄及基金收支表送監事會審核後造具審核意見書送還理事會提會員大

會通過於三月底前報主管機關核備(會員大會未能如期召開者需先報主管

機關備查)

第三十二條 本會解散後剩餘財產歸屬所在地之地方自治團體或主管機關指定之

機關團體所有

第三十三條 本章程未規定事項悉依有關法令規定辦理

第三十四條 本章程經大會通過報經主管機關核備後施行變更時亦同

第三十五條 本章程經本會民國八十五年二月四日第一屆第一次會員大會通過並報經內政

部 85年 3 月 14 日台(85)內社字第 8507009 號函准予備查

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

63

會 員 資 料 更 新 服 務

各位會員

您好如果您的會員資料有更新或誤刊情形麻煩您填妥表格後寄回學會秘書處或

電話連絡

中華民國比較病理學會秘書處

10617 臺北市大安區羅斯福路四段 1號

國立臺灣大學獸醫系三館 106 室 蕭世烜秘書長 收

Tel (02) 33663858

Fax (02) 23682423

e-mail address shsiao1ntuedutw

------------------------------中華民國比較病理學會----------------------------

會員資料更改卡

姓 名 會員類別一般會員

學生會員

贊助會員

最高學歷

服務單位 職 稱

永久地址

通訊地址

電 話 傳 真

E-Mail Address

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

64

中華民國比較病理學會

誠摯邀請您加入

入 會 辦 法

一本會會員申請資格為

(一)一般會員贊同本會宗旨年滿二十歲具有國內外大專院校(或同等學歷)生

命科學及其它相關科系畢業資格或高職畢業從事生命科學相關工作滿兩年者

(二)學生會員贊同本會宗旨在國內外大專院校生命科學或其他相關科系肄業者

(請檢附學生身份證明)

(三)贊助會員贊助本會工作之團體或個人

(四)榮譽會員凡對比較病理學術或會務之推廣有特殊貢獻經理事會提名並經會員

大會通過者

二會員

(一)入 會 費一般會員新台幣一仟元學生會員一佰元贊助會員伍仟元於入會

時繳納

(二)常年會費一般會員新台幣伍佰元學生會員一佰元

【註學生會員身份變更為一般會員時只需繳交一般會員之常年會費】

三請填妥入會申請表郵寄或傳真方式寄回中華民國比較病理學會秘書處收

地址10617 臺北市大安區羅斯福路四段 1號 國立臺灣大學獸醫系三館 106 室

蕭世烜秘書長 收

電話02-33663858傳真 02-23682423

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

65

中華民國比較病理學會入會申請及會員卡 會籍電腦編號

男 出生日期

民國 年 月 日

縣市

女 身份字號

會員身份一般學生贊助

1

稱謂醫師獸醫師先生小姐教授

主任研究員

2

1

3

2

4

3

機關名稱 職稱 起 止

年 月 年 月

年 月 年 月

年 月 年 月

年 月 年 月

通訊

戶籍

Email

電話

茲贊同

貴會宗旨妳加入為會員嗣後並願遵守一切規章共圖發展

此致

中華民國比較病理學會

申請人 簽章

介紹人 簽章

介紹人 簽章

中華民國 年 月 日

審核結果

66

獸醫三館

校園出入口

66

獸醫三館

校園出入口