, > : , 2070: , , : : : ,

1

Tab.1 ------------------------------------------------------------- 4050 60 70 80 90 2001 ------------------------------------------------------------- 47 56 52 30 26 6 217 42 28 6 3 1 0 80 5 28 46 27 25 6 137-------------------------------------------------------------

2

, .

2001-2005, 6

Tab.2 2001-2005

------------------------------------------------------------------------- ------------------------------------------------------------------------(telithromycin ) ()(biapenem) ()(ertapenem) ()(datomycin) (A-2197c)(caspofungin) (Pneumocandin in B0micafungin (Pneumocandin in A0)-----------------------------------------------------------------------------

()

12270

19811220011120149 104657513AIDS

(15.78%) (13.15%) (11.84%) (46.03%) (23.68%) 14.29%

20066-20076,187,3.0%126 ,67.37%, 39,21.05%,22,11.58%., 73.16%, 15%,3.2%

: : : 40%55%- 70% :85% :50% __

1

2 /

4

5

6 HIV/AIDS AIDS8590%

7

3 4 d ICU4 d >48 APACHE* II >10 TPN *APACHE = Acute Physiology and Chronic Health Evaluation.

2 (>105/ml)

__1,3-______ATP

; B, ;

B, .: ,.

,,,,,.B,,,,.

B(AMBL) , 50mg/ //EDTA-2Na/2 B(ABLC) B(ABCD), .

,,,,,,

: ___; () ___ : __; ;

1() , ,

2, ,

3

1

3

5-

2

P450, , 14-,___ AAAA

C1414CyP450-14 ____

CyP450-14DM,14 ___

CyP450-14DM

1 902 60803 4 80

Css56t1/2 t1/230h6.25~7.5d1

3.32t1/24.15dCss90 45d3.25~4t1/2

t1/2=30h Dmax=2.35D0Dmin= 1.35D0

S ED),.

2001611586(ARTEMIS)

(907/916; 99%)

(n=235) ( 218/235; 93%)(198/198; 100%)(150/150; 100%)(43/43; 100%)(24/24; 100%)Vori

Vori 10%CYP450(CYP3A4, CYP2C9, CYP2C19)

Itraconazole (35) 10mg/ml55 ,

2001FDA1 (CHF)

FDA24, 1124

CHF581345%

Am J Health Syst Pharm. 2001 Jun 15;58(12):1076.

: CYP4503A4,:CYP4503A4, CYP4502C9, CYP4502C19:CYP4503A4

__-1,3-D-

-1,3-D-,,, -1,3-D- -1,3-D-,,,,

-1,3-D-,,

,, ,,,-1,3-D-

(Caspofungin)

FDAB_______1 t1/29-11__2 t1/227,

__

97%,3041%,34%

__,,,,,,

CsA +CaspoCaspo AUC35%+CaspoC1226%,

(Micafungin) , 99.8% T1/2 1315h , 1% AUC A

Thank You !